TY - JOUR
T1 - Advances in pathogenesis and treatment of pruritus
AU - Bolier, Ruth
AU - Oude Elferink, Ronald P. J.
AU - Beuers, Ulrich
PY - 2013
Y1 - 2013
N2 - The pathogenesis of itch during cholestasis is largely unknown and treatment options are limited. Lysophosphatidate, female steroid hormones, and endogenous opioids are among the agents discussed as potential pruritogens in cholestasis. The itch-alleviating action of guideline-based therapeutic interventions with anion exchanger resins, rifampicin, opioid antagonists, and serotonin reuptake inhibitors are studied to unravel the molecular pathogenesis of itch. Still, a considerable part of the patients is in need of alternative experimental therapeutic approaches (eg, UV-B phototherapy, extracorporeal albumin dialysis, nasobiliary drainage), providing additional information about the enigmatic pathophysiology of cholestatic pruritus
AB - The pathogenesis of itch during cholestasis is largely unknown and treatment options are limited. Lysophosphatidate, female steroid hormones, and endogenous opioids are among the agents discussed as potential pruritogens in cholestasis. The itch-alleviating action of guideline-based therapeutic interventions with anion exchanger resins, rifampicin, opioid antagonists, and serotonin reuptake inhibitors are studied to unravel the molecular pathogenesis of itch. Still, a considerable part of the patients is in need of alternative experimental therapeutic approaches (eg, UV-B phototherapy, extracorporeal albumin dialysis, nasobiliary drainage), providing additional information about the enigmatic pathophysiology of cholestatic pruritus
U2 - https://doi.org/10.1016/j.cld.2012.11.006
DO - https://doi.org/10.1016/j.cld.2012.11.006
M3 - Article
C2 - 23540505
SN - 1089-3261
VL - 17
SP - 319
EP - 329
JO - Clinics in liver disease
JF - Clinics in liver disease
IS - 2
ER -