Abstract
The innate immune system provides the first line of defence against invading pathogens. Cells that mediate the innate immune response express a variety of receptors that permit recognition of pathogen-associated motifs, subsequently resulting in a cascade of responses that initiates inflammation. Recently, the members of the Toll-like receptor family (TLR) have emerged as key receptors responsible not only for the detection of a variety of microbial cell-wall components and bacterial DNA but also for the initiation of signal transduction events eventually leading to the production of various proinflammatory mediators
Original language | English |
---|---|
Pages (from-to) | 552-554 |
Journal | Wiener medizinische Wochenschrift (1946) |
Volume | 152 |
Issue number | 21-22 |
Publication status | Published - 2002 |