TY - JOUR
T1 - Adverse events of repetitive transcranial magnetic stimulation in older adults with depression, a systematic review of the literature
AU - Overvliet, Geke M.
AU - Jansen, Rebecca A. C.
AU - van Balkom, Anton J. L. M.
AU - van Campen, Dilene C.
AU - Oudega, Mardien L.
AU - van der Werf, Ysbrand D.
AU - van Exel, Eric
AU - van den Heuvel, Odile A.
AU - Dols, Annemiek
N1 - Funding Information: Odile A. van den Heuvel reports grants from Parkinson Vereniging, grants from Hersenstichting Nederland, grants from NWO‐ZonMw, other from Benecke, grants from National Institute of Mental Health, outside the submitted work. This has no influence on the submitted work. Remaining authors have no disclosure or financial or personal relationship with other people or organisations that could inappropriately influence the work. Publisher Copyright: © 2020 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/3
Y1 - 2021/3
N2 - Objective: In the last decade, repetitive transcranial magnetic stimulation (rTMS) has been introduced as a non-invasive neuromodulation therapy for depression. Little is known, however, about (serious) adverse events (AE) of rTMS in older adults with a depression. In this article, we want to study what is known about (serious) AE of rTMS in older adults (>60 years) with late-life depression (LLD). Methods: A systematic search has been performed according to the PRISMA guidelines in PubMed, EMBase and PsycInfo. We have screened 622 articles for eligibility. Eleven studies, evaluating 353 patients in total, were included in this review. Results: AE were reported in 12.4% of the older adults with a LLD treated with rTMS, serious AE in 1.5%. Headache (6.9%) and discomfort at the stimulation site (2.7%) are the most commonly reported AE. Serious AE reported are: psychiatric hospitalization (three times), a combination of posterior vitreous detachment and retinal tear, and increased suicide ideation (both once). Conclusions: rTMS in older adults with LLD was concluded overall to be safe due to the low frequency of AE reported in trials and observational studies. In case-reports, however, more serious AE have been described. To tailor use of rTMS in older adults with LLD, more research is needed in larger samples to optimize tolerance.
AB - Objective: In the last decade, repetitive transcranial magnetic stimulation (rTMS) has been introduced as a non-invasive neuromodulation therapy for depression. Little is known, however, about (serious) adverse events (AE) of rTMS in older adults with a depression. In this article, we want to study what is known about (serious) AE of rTMS in older adults (>60 years) with late-life depression (LLD). Methods: A systematic search has been performed according to the PRISMA guidelines in PubMed, EMBase and PsycInfo. We have screened 622 articles for eligibility. Eleven studies, evaluating 353 patients in total, were included in this review. Results: AE were reported in 12.4% of the older adults with a LLD treated with rTMS, serious AE in 1.5%. Headache (6.9%) and discomfort at the stimulation site (2.7%) are the most commonly reported AE. Serious AE reported are: psychiatric hospitalization (three times), a combination of posterior vitreous detachment and retinal tear, and increased suicide ideation (both once). Conclusions: rTMS in older adults with LLD was concluded overall to be safe due to the low frequency of AE reported in trials and observational studies. In case-reports, however, more serious AE have been described. To tailor use of rTMS in older adults with LLD, more research is needed in larger samples to optimize tolerance.
KW - adverse events
KW - late life depression
KW - older adults
KW - repetitive transcranial magnetic stimulation
KW - serious adverse events
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85096636602&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/33156540
U2 - https://doi.org/10.1002/gps.5440
DO - https://doi.org/10.1002/gps.5440
M3 - Review article
C2 - 33156540
SN - 0885-6230
VL - 36
SP - 383
EP - 392
JO - International journal of geriatric psychiatry
JF - International journal of geriatric psychiatry
IS - 3
ER -