TY - JOUR
T1 - Affective and psychotic reactivity to daily-life stress in adults with 22q11DS: a study using the experience sampling method
AU - Schneider, Maude
AU - Vaessen, Thomas
AU - van Duin, Esther D. A.
AU - Kasanova, Zuzana
AU - Viechtbauer, Wolfgang
AU - Reininghaus, Ulrich
AU - Vingerhoets, Claudia
AU - Booij, Jan
AU - Swillen, Ann
AU - Vorstman, Jacob A. S.
AU - van Amelsvoort, Thérèse
AU - Myin-Germeys, Inez
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Background: 22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with an increased risk of psychiatric disorders. Vulnerability for psychopathology has been related to an increased reactivity to stress. Here, we examined affective states, perceived stress, affective and psychotic reactivity to various sources of environmental stress using the experience sampling method (ESM), a structured diary technique allowing repeated assessments in the context of daily life. Methods: Adults with 22q11DS (n = 31; age, 34.1 years) and matched healthy controls (HCs; n = 24; age, 39.9 years) were included. ESM was used to assess affective states, perceived stress, and stress reactivity. Data were analyzed using multilevel regression models. Results: Adults with 22q11DS displayed overall higher levels of negative affect but comparable levels of positive affect compared to HCs. Higher levels of perceived stress were reported by individuals with 22q11DS. Comparable affective and psychotic reactivity in relation to all types of environmental stress was observed between the two groups. Conclusion: The results point toward higher levels of negative affect and differences in the perception of daily hassles in 22q11DS but no difference in affective or psychotic reactivity to stress. This study contributes to the growing literature regarding the impact of stress on the development of psychopathology in the 22q11DS population.
AB - Background: 22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with an increased risk of psychiatric disorders. Vulnerability for psychopathology has been related to an increased reactivity to stress. Here, we examined affective states, perceived stress, affective and psychotic reactivity to various sources of environmental stress using the experience sampling method (ESM), a structured diary technique allowing repeated assessments in the context of daily life. Methods: Adults with 22q11DS (n = 31; age, 34.1 years) and matched healthy controls (HCs; n = 24; age, 39.9 years) were included. ESM was used to assess affective states, perceived stress, and stress reactivity. Data were analyzed using multilevel regression models. Results: Adults with 22q11DS displayed overall higher levels of negative affect but comparable levels of positive affect compared to HCs. Higher levels of perceived stress were reported by individuals with 22q11DS. Comparable affective and psychotic reactivity in relation to all types of environmental stress was observed between the two groups. Conclusion: The results point toward higher levels of negative affect and differences in the perception of daily hassles in 22q11DS but no difference in affective or psychotic reactivity to stress. This study contributes to the growing literature regarding the impact of stress on the development of psychopathology in the 22q11DS population.
KW - 22q11.2 deletion syndrome
KW - Experience sampling method
KW - Momentary psychotic experiences
KW - Negative affect
KW - Positive affect
KW - Stress reactivity
UR - http://www.scopus.com/inward/record.url?scp=85095944884&partnerID=8YFLogxK
U2 - https://doi.org/10.1186/s11689-020-09333-2
DO - https://doi.org/10.1186/s11689-020-09333-2
M3 - Article
C2 - 33187471
SN - 1866-1947
VL - 12
JO - Journal of neurodevelopmental disorders
JF - Journal of neurodevelopmental disorders
IS - 1
M1 - 30
ER -