TY - JOUR
T1 - Age and gender-specific reference values of orbital fat and muscle volumes in Caucasians
AU - Regensburg, N.I.
AU - Wiersinga, W.M.
AU - van Velthoven, M.E.J.
AU - Berendschot, T.T.J.M.
AU - Zonneveld, F.W.
AU - Baldeschi, L.
AU - Saeed, P.
AU - Mourits, M.P.
PY - 2011
Y1 - 2011
N2 - To provide age and gender-specific reference values for orbital fat and muscle volumes (MV) in Caucasian adults. Computed tomographic scans of 160 orbits from 52 men and 55 women, aged 20-80 years, not affected by orbital disease were evaluated. Orbital bony cavity volume (OV), fat volume (FV) and MV were calculated by a previously validated method using the software program Mimics. Ratios of FV to OV and of MV to OV were determined. OV, FV and MV were all significantly larger in men than in women (p<0.001), but FV/OV and MV/OV were similar in both sexes. OV and MV did not change with age, but FV increased with advancing age in both women (p<0.001) and men (p<0.001). Linear regression analysis with FV/OV and MV/OV ratios as dependent variables and age and gender as independent variables showed a significant correlation between age and FV/OV (r=0.52, p<0.0001) and age and MV/OV (r=-0.26, p=0.001). Advancing age is associated with an increase of FV/OV and a minor decrease of MV/OV. Gender-specific differences in orbital FV and MV disappear once FV and MV are related to OV, by calculating the ratios FV/OV and MV/OV. Age-specific gender-neutral reference ranges (2.5 and 97.5 percentiles) of FV/OV and MV/OV are presented
AB - To provide age and gender-specific reference values for orbital fat and muscle volumes (MV) in Caucasian adults. Computed tomographic scans of 160 orbits from 52 men and 55 women, aged 20-80 years, not affected by orbital disease were evaluated. Orbital bony cavity volume (OV), fat volume (FV) and MV were calculated by a previously validated method using the software program Mimics. Ratios of FV to OV and of MV to OV were determined. OV, FV and MV were all significantly larger in men than in women (p<0.001), but FV/OV and MV/OV were similar in both sexes. OV and MV did not change with age, but FV increased with advancing age in both women (p<0.001) and men (p<0.001). Linear regression analysis with FV/OV and MV/OV ratios as dependent variables and age and gender as independent variables showed a significant correlation between age and FV/OV (r=0.52, p<0.0001) and age and MV/OV (r=-0.26, p=0.001). Advancing age is associated with an increase of FV/OV and a minor decrease of MV/OV. Gender-specific differences in orbital FV and MV disappear once FV and MV are related to OV, by calculating the ratios FV/OV and MV/OV. Age-specific gender-neutral reference ranges (2.5 and 97.5 percentiles) of FV/OV and MV/OV are presented
U2 - https://doi.org/10.1136/bjo.2009.161372
DO - https://doi.org/10.1136/bjo.2009.161372
M3 - Article
C2 - 19955201
SN - 0007-1161
VL - 95
SP - 1660
EP - 1663
JO - British journal of ophthalmology
JF - British journal of ophthalmology
IS - 12
ER -