TY - JOUR
T1 - Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure
AU - Vriend, Chris
AU - de Joode, Niels T
AU - Pouwels, Petra J W
AU - Liu, Feng
AU - Otaduy, Maria C G
AU - Pastorello, Bruno
AU - Robertson, Frances C
AU - Ipser, Jonathan
AU - Lee, Seonjoo
AU - Hezel, Dianne M
AU - van Meter, Page E
AU - Batistuzzo, Marcelo C
AU - Hoexter, Marcelo Q
AU - Sheshachala, Karthik
AU - Narayanaswamy, Janardhanan C
AU - Venkatasubramanian, Ganesan
AU - Lochner, Christine
AU - Miguel, Euripedes C
AU - Reddy, Y C Janardhan
AU - Shavitt, Roseli G
AU - Stein, Dan J
AU - Wall, Melanie
AU - Simpson, Helen Blair
AU - van den Heuvel, Odile A
N1 - Funding Information: This study was funded by the National Institute of Mental Health, Grant Award Number: R01 MH113250. DJS has received consultancy honoraria from Discovery Vitality, Johnson & Johnson, Kanna, L’Oreal, Lundbeck, Orion, Sanofi, Servier, Takeda and Vistagen. RGS receives research grants not related to this work from the National Council for Scientific and Technological Development––CNPq #307386/2021-0; 402628/2019-5 and the Sao Paulo Research Foundation (FAPESP, #2019/27250-3). Publisher Copyright: © 2024, The Author(s).
PY - 2024/1/16
Y1 - 2024/1/16
N2 - Previous diffusion MRI studies have reported mixed findings on white matter microstructure alterations in obsessive-compulsive disorder (OCD), likely due to variation in demographic and clinical characteristics, scanning methods, and underpowered samples. The OCD global study was created across five international sites to overcome these challenges by harmonizing data collection to identify consistent brain signatures of OCD that are reproducible and generalizable. Single-shell diffusion measures (e.g., fractional anisotropy), multi-shell Neurite Orientation Dispersion and Density Imaging (NODDI) and fixel-based measures, were extracted from skeletonized white matter tracts in 260 medication-free adults with OCD and 252 healthy controls. We additionally performed structural connectome analysis. We compared cases with controls and cases with early (<18) versus late (18+) OCD onset using mixed-model and Bayesian multilevel analysis. Compared with healthy controls, adult OCD individuals showed higher fiber density in the sagittal stratum (B[SE] = 0.10[0.05], P = 0.04) and credible evidence for higher fiber density in several other tracts. When comparing early (n = 145) and late-onset (n = 114) cases, converging evidence showed lower integrity of the posterior thalamic radiation -particularly radial diffusivity (B[SE] = 0.28[0.12], P = 0.03)-and lower global efficiency of the structural connectome (B[SE] = 15.3[6.6], P = 0.03) in late-onset cases. Post-hoc analyses indicated divergent direction of effects of the two OCD groups compared to healthy controls. Age of OCD onset differentially affects the integrity of thalamo-parietal/occipital tracts and the efficiency of the structural brain network. These results lend further support for the role of the thalamus and its afferent fibers and visual attentional processes in the pathophysiology of OCD.
AB - Previous diffusion MRI studies have reported mixed findings on white matter microstructure alterations in obsessive-compulsive disorder (OCD), likely due to variation in demographic and clinical characteristics, scanning methods, and underpowered samples. The OCD global study was created across five international sites to overcome these challenges by harmonizing data collection to identify consistent brain signatures of OCD that are reproducible and generalizable. Single-shell diffusion measures (e.g., fractional anisotropy), multi-shell Neurite Orientation Dispersion and Density Imaging (NODDI) and fixel-based measures, were extracted from skeletonized white matter tracts in 260 medication-free adults with OCD and 252 healthy controls. We additionally performed structural connectome analysis. We compared cases with controls and cases with early (<18) versus late (18+) OCD onset using mixed-model and Bayesian multilevel analysis. Compared with healthy controls, adult OCD individuals showed higher fiber density in the sagittal stratum (B[SE] = 0.10[0.05], P = 0.04) and credible evidence for higher fiber density in several other tracts. When comparing early (n = 145) and late-onset (n = 114) cases, converging evidence showed lower integrity of the posterior thalamic radiation -particularly radial diffusivity (B[SE] = 0.28[0.12], P = 0.03)-and lower global efficiency of the structural connectome (B[SE] = 15.3[6.6], P = 0.03) in late-onset cases. Post-hoc analyses indicated divergent direction of effects of the two OCD groups compared to healthy controls. Age of OCD onset differentially affects the integrity of thalamo-parietal/occipital tracts and the efficiency of the structural brain network. These results lend further support for the role of the thalamus and its afferent fibers and visual attentional processes in the pathophysiology of OCD.
UR - http://www.scopus.com/inward/record.url?scp=85182461280&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41380-023-02390-8
DO - https://doi.org/10.1038/s41380-023-02390-8
M3 - Article
C2 - 38228890
SN - 1359-4184
JO - Molecular psychiatry
JF - Molecular psychiatry
ER -