TY - JOUR
T1 - Age-related and regional changes of aortic stiffness in the Marfan syndrome
T2 - Assessment with velocity-encoded MRI
AU - Westenberg, Jos J.M.
AU - Scholte, Arthur J.H.A.
AU - Vaskova, Zuzana
AU - Van Der Geest, Rob J.
AU - Groenink, Maarten
AU - Labadie, Gerda
AU - Van Den Boogaard, Pieter J.
AU - Radonic, Teodora
AU - Hilhorst-Hofstee, Yvonne
AU - Mulder, Barbara J.M.
AU - Kroft, Lucia J.M.
AU - Reiber, Johan H.C.
AU - De Roos, Albert
PY - 2011/9
Y1 - 2011/9
N2 - Purpose: To study age-related change in aortic stiffness in patients with Marfan syndrome (MFS) versus healthy volunteers using velocity-encoded (VE) MRI. Materials and Methods: Twenty-five MFS patients (age range, 18-63 years; mean age 36 ± 14 years, 13 men) and 25 age-/gender-matched healthy volunteers were examined with VE-MRI. Aortic stiffness was expressed by pulse wave velocity (PWV), assessed in the proximal and distal part of the aorta and in the total aorta. PWV was compared between patients and volunteers and age-relation was determined by linear regression. Results: PWV was significantly higher in all parts of the aorta in patients when compared with healthy volunteers (proximal aorta 5.7 ± 1.5 m/s versus 4.8 ± 0.9 m/s, distal aorta 6.4 ± 2.4 m/s versus 5.0 ± 1.2 m/s and total aorta 5.9 ± 1.7 m/s versus 4.9 ± 1.1 m/s, all P < 0.004). PWV correlated significantly with age (Pearson R between 0.45 and 0.94). Only in the proximal aorta, the increase in PWV with age was significantly higher in patients (7 ± 2 cm/s increase with age) than in volunteers (3 ± 1 cm/s increase, P = 0.03); in the distal or total aorta, the increase in PWV with age was not different between patients and volunteers. Conclusion: Velocity-encoded MRI detects more pronounced age-related aortic stiffening in the proximal aorta in MFS patients versus healthy volunteers, suggesting more severe wall disease in MFS.
AB - Purpose: To study age-related change in aortic stiffness in patients with Marfan syndrome (MFS) versus healthy volunteers using velocity-encoded (VE) MRI. Materials and Methods: Twenty-five MFS patients (age range, 18-63 years; mean age 36 ± 14 years, 13 men) and 25 age-/gender-matched healthy volunteers were examined with VE-MRI. Aortic stiffness was expressed by pulse wave velocity (PWV), assessed in the proximal and distal part of the aorta and in the total aorta. PWV was compared between patients and volunteers and age-relation was determined by linear regression. Results: PWV was significantly higher in all parts of the aorta in patients when compared with healthy volunteers (proximal aorta 5.7 ± 1.5 m/s versus 4.8 ± 0.9 m/s, distal aorta 6.4 ± 2.4 m/s versus 5.0 ± 1.2 m/s and total aorta 5.9 ± 1.7 m/s versus 4.9 ± 1.1 m/s, all P < 0.004). PWV correlated significantly with age (Pearson R between 0.45 and 0.94). Only in the proximal aorta, the increase in PWV with age was significantly higher in patients (7 ± 2 cm/s increase with age) than in volunteers (3 ± 1 cm/s increase, P = 0.03); in the distal or total aorta, the increase in PWV with age was not different between patients and volunteers. Conclusion: Velocity-encoded MRI detects more pronounced age-related aortic stiffening in the proximal aorta in MFS patients versus healthy volunteers, suggesting more severe wall disease in MFS.
KW - Marfan syndrome
KW - aging
KW - aortic stiffness
KW - elasticity
KW - magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=80051938524&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/jmri.22646
DO - https://doi.org/10.1002/jmri.22646
M3 - Article
C2 - 21761466
SN - 1053-1807
VL - 34
SP - 526
EP - 531
JO - Journal of magnetic resonance imaging
JF - Journal of magnetic resonance imaging
IS - 3
ER -