Age-related differences in plasmalogen content of erythrocytes from patients with the cerebro-hepato-renal (Zellweger) syndrome: implications for postnatal detection of the disease

R. J. Wanders; Y. R. Purvis; H. S. Heymans; J. A. Bakkeren; G. G. Parmentier; J. van Eldere; H. Eyssen; H. van den Bosch; J. M. Tager; R. B. Schutgens

doi:https://doi.org/10.1007/BF01800482

Age-related differences in plasmalogen content of erythrocytes from patients with the cerebro-hepato-renal (Zellweger) syndrome: implications for postnatal detection of the disease

R. J. Wanders, Y. R. Purvis, H. S. Heymans, J. A. Bakkeren, G. G. Parmentier, J. van Eldere, H. Eyssen, H. van den Bosch, J. M. Tager, R. B. Schutgens

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Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Phosphatidylethanolamine plasmalogen levels were determined in erythrocytes from controls and 13 patients with the cerebro-hepato-renal (Zellweger) syndrome. It was found that in Zellweger patients 20 weeks of age or younger, erythrocyte phosphatidylethanolamine plasmalogen levels were lowered whereas in older patients (except in one) normal levels were found. The results obtained suggest a close relationship between the age of the patients at sampling and the phosphatidylethanolamine plasmalogen levels in their erythrocytes. A possible explanation for these findings and the implications for the postnatal detection of Zellweger syndrome are discussed

Original language	English
Pages (from-to)	335-342
Journal	Journal of Inherited Metabolic Disease
Volume	9
Issue number	4
DOIs	https://doi.org/10.1007/BF01800482
Publication status	Published - 1986

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Wanders, R. J., Purvis, Y. R., Heymans, H. S., Bakkeren, J. A., Parmentier, G. G., van Eldere, J., Eyssen, H., van den Bosch, H., Tager, J. M., & Schutgens, R. B. (1986). Age-related differences in plasmalogen content of erythrocytes from patients with the cerebro-hepato-renal (Zellweger) syndrome: implications for postnatal detection of the disease. Journal of Inherited Metabolic Disease, 9(4), 335-342. https://doi.org/10.1007/BF01800482

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title = "Age-related differences in plasmalogen content of erythrocytes from patients with the cerebro-hepato-renal (Zellweger) syndrome: implications for postnatal detection of the disease",

abstract = "Phosphatidylethanolamine plasmalogen levels were determined in erythrocytes from controls and 13 patients with the cerebro-hepato-renal (Zellweger) syndrome. It was found that in Zellweger patients 20 weeks of age or younger, erythrocyte phosphatidylethanolamine plasmalogen levels were lowered whereas in older patients (except in one) normal levels were found. The results obtained suggest a close relationship between the age of the patients at sampling and the phosphatidylethanolamine plasmalogen levels in their erythrocytes. A possible explanation for these findings and the implications for the postnatal detection of Zellweger syndrome are discussed",

author = "Wanders, {R. J.} and Purvis, {Y. R.} and Heymans, {H. S.} and Bakkeren, {J. A.} and Parmentier, {G. G.} and {van Eldere}, J. and H. Eyssen and {van den Bosch}, H. and Tager, {J. M.} and Schutgens, {R. B.}",

year = "1986",

doi = "https://doi.org/10.1007/BF01800482",

language = "English",

volume = "9",

pages = "335--342",

journal = "Journal of Inherited Metabolic Disease",

issn = "0141-8955",

publisher = "Springer Netherlands",

number = "4",

}

Wanders, RJ, Purvis, YR, Heymans, HS, Bakkeren, JA, Parmentier, GG, van Eldere, J, Eyssen, H, van den Bosch, H, Tager, JM & Schutgens, RB 1986, 'Age-related differences in plasmalogen content of erythrocytes from patients with the cerebro-hepato-renal (Zellweger) syndrome: implications for postnatal detection of the disease', Journal of Inherited Metabolic Disease, vol. 9, no. 4, pp. 335-342. https://doi.org/10.1007/BF01800482

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Age-related differences in plasmalogen content of erythrocytes from patients with the cerebro-hepato-renal (Zellweger) syndrome: implications for postnatal detection of the disease

AU - Wanders, R. J.

AU - Purvis, Y. R.

AU - Heymans, H. S.

AU - Bakkeren, J. A.

AU - Parmentier, G. G.

AU - van Eldere, J.

AU - Eyssen, H.

AU - van den Bosch, H.

AU - Tager, J. M.

AU - Schutgens, R. B.

PY - 1986

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AB - Phosphatidylethanolamine plasmalogen levels were determined in erythrocytes from controls and 13 patients with the cerebro-hepato-renal (Zellweger) syndrome. It was found that in Zellweger patients 20 weeks of age or younger, erythrocyte phosphatidylethanolamine plasmalogen levels were lowered whereas in older patients (except in one) normal levels were found. The results obtained suggest a close relationship between the age of the patients at sampling and the phosphatidylethanolamine plasmalogen levels in their erythrocytes. A possible explanation for these findings and the implications for the postnatal detection of Zellweger syndrome are discussed

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DO - https://doi.org/10.1007/BF01800482

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SN - 0141-8955

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SP - 335

EP - 342

JO - Journal of Inherited Metabolic Disease

JF - Journal of Inherited Metabolic Disease

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