TY - JOUR
T1 - Aging modifies the effect of cardiac output on middle cerebral artery blood flow velocity
AU - Bronzwaer, Anne-Sophie G. T.
AU - Verbree, Jasper
AU - Stok, Wim J.
AU - Daemen, Mat J. A. P.
AU - van Buchem, Mark A.
AU - van Osch, Matthias J. P.
AU - van Lieshout, Johannes J.
PY - 2017
Y1 - 2017
N2 - An association between cerebral blood flow (CBF) and cardiac output (CO) has been established in young healthy subjects. As of yet it is unclear how this association evolves over the life span. To that purpose, we continuously recorded mean arterial pressure (MAP; finger plethysmography), CO (pulse contour; CO‐trek), mean blood flow velocity in the middle cerebral artery (MCAV; transcranial Doppler ultrasonography), and end‐tidal CO2 partial pressure (PetCO2) in healthy young (19–27 years), middle‐aged (51–61 years), and elderly subjects (70–79 years). Decreases and increases in CO were accomplished using lower body negative pressure and dynamic handgrip exercise, respectively. Aging in itself did not alter dynamic cerebral autoregulation or cerebrovascular CO2 reactivity. A linear relation between changes in CO and MCAVmean was observed in middle‐aged (P < 0.01) and elderly (P = 0.04) subjects but not in young (P = 0.45) subjects, taking concurrent changes in MAP and PetCO2 into account. These data imply that with aging, brain perfusion becomes increasingly dependent on CO.
AB - An association between cerebral blood flow (CBF) and cardiac output (CO) has been established in young healthy subjects. As of yet it is unclear how this association evolves over the life span. To that purpose, we continuously recorded mean arterial pressure (MAP; finger plethysmography), CO (pulse contour; CO‐trek), mean blood flow velocity in the middle cerebral artery (MCAV; transcranial Doppler ultrasonography), and end‐tidal CO2 partial pressure (PetCO2) in healthy young (19–27 years), middle‐aged (51–61 years), and elderly subjects (70–79 years). Decreases and increases in CO were accomplished using lower body negative pressure and dynamic handgrip exercise, respectively. Aging in itself did not alter dynamic cerebral autoregulation or cerebrovascular CO2 reactivity. A linear relation between changes in CO and MCAVmean was observed in middle‐aged (P < 0.01) and elderly (P = 0.04) subjects but not in young (P = 0.45) subjects, taking concurrent changes in MAP and PetCO2 into account. These data imply that with aging, brain perfusion becomes increasingly dependent on CO.
U2 - https://doi.org/10.14814/phy2.13361
DO - https://doi.org/10.14814/phy2.13361
M3 - Article
C2 - 28912128
SN - 2051-817X
VL - 5
JO - Physiological reports
JF - Physiological reports
IS - 17
M1 - e13361
ER -