Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids

Lisette I. Z. Kunz; Nick H. T. ten Hacken; Thérèse S. Lapperre; Wim Timens; Huib A. M. Kerstjens; Annemarie van Schadewijk; Judith M. Vonk; Jacob K. Sont; Jiska B. Snoeck-Stroband; Dirkje S. Postma; Peter J. Sterk; Pieter S. Hiemstra

doi:https://doi.org/10.1183/13993003.00839-2016

Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids

Lisette I. Z. Kunz, Nick H. T. ten Hacken, Thérèse S. Lapperre, Wim Timens, Huib A. M. Kerstjens, Annemarie van Schadewijk, Judith M. Vonk, Jacob K. Sont, Jiska B. Snoeck-Stroband, Dirkje S. Postma, Peter J. Sterk, Pieter S. Hiemstra

Research output: Contribution to journal › Article › Academic › peer-review

28 Citations (Scopus)

Abstract

+cells (1.71, 95% CI 1.15-2.53), and mast cells (1.91, 95% CI 1.36-2.68). The sputum total cell counts increased significantly in GL2 (1.90, 95% CI 1.42-2.54), as did counts of macrophages (2.10, 95% CI 1.55-2.86), neutrophils (1.92, 95% CI 1.39-2.65) and lymphocytes (2.01, 95% CI 1.46-2.78).ICS discontinuation increases airway inflammation in patients with moderate-severe COPD, suggesting that the anti-inflammatory effects of ICS in COPD are not maintained after ICS discontinuation

Original language	English
Pages (from-to)	1600839
Journal	European respiratory journal
Volume	49
Issue number	1
Early online date	2017
DOIs	https://doi.org/10.1183/13993003.00839-2016
Publication status	Published - 2017

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https://doi.org/10.1183/13993003.00839-2016

Cite this

Kunz, L. I. Z., ten Hacken, N. H. T., Lapperre, T. S., Timens, W., Kerstjens, H. A. M., van Schadewijk, A., Vonk, J. M., Sont, J. K., Snoeck-Stroband, J. B., Postma, D. S., Sterk, P. J., & Hiemstra, P. S. (2017). Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids. European respiratory journal, 49(1), 1600839. https://doi.org/10.1183/13993003.00839-2016

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title = "Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids",

abstract = "+cells (1.71, 95% CI 1.15-2.53), and mast cells (1.91, 95% CI 1.36-2.68). The sputum total cell counts increased significantly in GL2 (1.90, 95% CI 1.42-2.54), as did counts of macrophages (2.10, 95% CI 1.55-2.86), neutrophils (1.92, 95% CI 1.39-2.65) and lymphocytes (2.01, 95% CI 1.46-2.78).ICS discontinuation increases airway inflammation in patients with moderate-severe COPD, suggesting that the anti-inflammatory effects of ICS in COPD are not maintained after ICS discontinuation",

author = "Kunz, {Lisette I. Z.} and {ten Hacken}, {Nick H. T.} and Lapperre, {Th{\'e}r{\`e}se S.} and Wim Timens and Kerstjens, {Huib A. M.} and {van Schadewijk}, Annemarie and Vonk, {Judith M.} and Sont, {Jacob K.} and Snoeck-Stroband, {Jiska B.} and Postma, {Dirkje S.} and Sterk, {Peter J.} and Hiemstra, {Pieter S.}",

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T1 - Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids

AU - Kunz, Lisette I. Z.

AU - ten Hacken, Nick H. T.

AU - Lapperre, Thérèse S.

AU - Timens, Wim

AU - Kerstjens, Huib A. M.

AU - van Schadewijk, Annemarie

AU - Vonk, Judith M.

AU - Sont, Jacob K.

AU - Snoeck-Stroband, Jiska B.

AU - Postma, Dirkje S.

AU - Sterk, Peter J.

AU - Hiemstra, Pieter S.

N1 - Onterecht samengevoegd met PMID 28619964

PY - 2017

Y1 - 2017

N2 - +cells (1.71, 95% CI 1.15-2.53), and mast cells (1.91, 95% CI 1.36-2.68). The sputum total cell counts increased significantly in GL2 (1.90, 95% CI 1.42-2.54), as did counts of macrophages (2.10, 95% CI 1.55-2.86), neutrophils (1.92, 95% CI 1.39-2.65) and lymphocytes (2.01, 95% CI 1.46-2.78).ICS discontinuation increases airway inflammation in patients with moderate-severe COPD, suggesting that the anti-inflammatory effects of ICS in COPD are not maintained after ICS discontinuation

AB - +cells (1.71, 95% CI 1.15-2.53), and mast cells (1.91, 95% CI 1.36-2.68). The sputum total cell counts increased significantly in GL2 (1.90, 95% CI 1.42-2.54), as did counts of macrophages (2.10, 95% CI 1.55-2.86), neutrophils (1.92, 95% CI 1.39-2.65) and lymphocytes (2.01, 95% CI 1.46-2.78).ICS discontinuation increases airway inflammation in patients with moderate-severe COPD, suggesting that the anti-inflammatory effects of ICS in COPD are not maintained after ICS discontinuation

U2 - https://doi.org/10.1183/13993003.00839-2016

DO - https://doi.org/10.1183/13993003.00839-2016

M3 - Article

C2 - 28049170

SN - 0903-1936

VL - 49

SP - 1600839

JO - European respiratory journal

JF - European respiratory journal

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ER -