Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids

Lisette I. Z. Kunz, Nick H. T. ten Hacken, Thérèse S. Lapperre, Wim Timens, Huib A. M. Kerstjens, Annemarie van Schadewijk, Judith M. Vonk, Jacob K. Sont, Jiska B. Snoeck-Stroband, Dirkje S. Postma, Peter J. Sterk, Pieter S. Hiemstra

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Abstract

+cells (1.71, 95% CI 1.15-2.53), and mast cells (1.91, 95% CI 1.36-2.68). The sputum total cell counts increased significantly in GL2 (1.90, 95% CI 1.42-2.54), as did counts of macrophages (2.10, 95% CI 1.55-2.86), neutrophils (1.92, 95% CI 1.39-2.65) and lymphocytes (2.01, 95% CI 1.46-2.78).ICS discontinuation increases airway inflammation in patients with moderate-severe COPD, suggesting that the anti-inflammatory effects of ICS in COPD are not maintained after ICS discontinuation
Original languageEnglish
Pages (from-to)1600839
JournalEuropean respiratory journal
Volume49
Issue number1
Early online date2017
DOIs
Publication statusPublished - 2017

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