TY - JOUR
T1 - Altered microRNA processing proteins in HPV-induced cancers
AU - Snoek, Barbara C.
AU - Babion, Iris
AU - Koppers-Lalic, Danijela
AU - Pegtel, Dirk M.
AU - Steenbergen, Renske DM
N1 - Funding Information: The authors are grateful to Dr. Saskia M. Wilting for providing mRNA expression data of cervical tissues, and Marieke Dekker for her assistance during the early stages of writing the article. This work was supported by the Dutch Cancer Society ( KWF-10395 ). The source of funding did not have any influence on the design of the study, collection, analysis, interpretation of the data, in writing the manuscript, and in the decision to submit the article for publication. Funding Information: The authors are grateful to Dr. Saskia M. Wilting for providing mRNA expression data of cervical tissues, and Marieke Dekker for her assistance during the early stages of writing the article. This work was supported by the Dutch Cancer Society (KWF-10395). The source of funding did not have any influence on the design of the study, collection, analysis, interpretation of the data, in writing the manuscript, and in the decision to submit the article for publication. Publisher Copyright: © 2019 The Authors
PY - 2019/12/1
Y1 - 2019/12/1
N2 - High-risk human papilloma virus (hrHPV) infections are associated with the development of anogenital cancers, in particular cervical cancer, and a subset of head and neck cancers. Previous studies have shown that microRNAs (miRNAs) contribute to the development and progression of HPV-induced malignancies. miRNAs are small non-coding RNAs that exist as multiple length and sequence variants, termed isomiRs. Efficient processing of miRNAs and generation of isomiRs is accomplished by several processing proteins. Deregulation of Drosha, AGO2, and TENT2, among others, has been observed in HPV-induced cancers and was even found at the precancerous stage. This suggests that miRNA processing proteins may be involved during early cancer development and that the generated isomiRs could provide promising biomarkers for early cancer diagnosis.
AB - High-risk human papilloma virus (hrHPV) infections are associated with the development of anogenital cancers, in particular cervical cancer, and a subset of head and neck cancers. Previous studies have shown that microRNAs (miRNAs) contribute to the development and progression of HPV-induced malignancies. miRNAs are small non-coding RNAs that exist as multiple length and sequence variants, termed isomiRs. Efficient processing of miRNAs and generation of isomiRs is accomplished by several processing proteins. Deregulation of Drosha, AGO2, and TENT2, among others, has been observed in HPV-induced cancers and was even found at the precancerous stage. This suggests that miRNA processing proteins may be involved during early cancer development and that the generated isomiRs could provide promising biomarkers for early cancer diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=85070323084&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.coviro.2019.07.002
DO - https://doi.org/10.1016/j.coviro.2019.07.002
M3 - Review article
C2 - 31408800
SN - 1879-6257
VL - 39
SP - 23
EP - 32
JO - Current opinion in virology
JF - Current opinion in virology
ER -