TY - JOUR
T1 - Alternative macroautophagic pathways
AU - Juenemann, Katrin
AU - Reits, Eric A.
PY - 2012
Y1 - 2012
N2 - Macroautophagy is a bulk degradation process that mediates the clearance of long-lived proteins, aggregates, or even whole organelles. This process includes the formation of autophagosomes, double-membrane structures responsible for delivering cargo to lysosomes for degradation. Currently, other alternative autophagy pathways have been described, which are independent of macroautophagic key players like Atg5 and Beclin 1 or the lipidation of LC3. In this review, we highlight recent insights in indentifying and understanding the molecular mechanism responsible for alternative autophagic pathways
AB - Macroautophagy is a bulk degradation process that mediates the clearance of long-lived proteins, aggregates, or even whole organelles. This process includes the formation of autophagosomes, double-membrane structures responsible for delivering cargo to lysosomes for degradation. Currently, other alternative autophagy pathways have been described, which are independent of macroautophagic key players like Atg5 and Beclin 1 or the lipidation of LC3. In this review, we highlight recent insights in indentifying and understanding the molecular mechanism responsible for alternative autophagic pathways
U2 - https://doi.org/10.1155/2012/189794
DO - https://doi.org/10.1155/2012/189794
M3 - Article
C2 - 22536246
SN - 1687-8884
VL - 2012
SP - 189794
JO - International Journal of Cell Biology
JF - International Journal of Cell Biology
ER -