TY - JOUR
T1 - Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene
AU - van de Vijver, M.
AU - van de Bersselaar, R.
AU - Devilee, P.
AU - Cornelisse, C.
AU - Peterse, J.
AU - Nusse, R.
PY - 1987
Y1 - 1987
N2 - We investigated alterations in the structure and expression of oncogenes in mammary tumors and mammary tumor-derived cell lines. In 16 of 95 samples, we detected amplification of the human neu oncogene, also known as c-erB-2, accompanied by overexpression in the tumors from which intact RNA could be isolated. In 10 of these DNAs, the linked oncogene c-erbA was also amplified, whereas another gene on human chromosome 17, p53, was present in normal copy numbers. Overexpression of c-erbA could not be detected in the tumors analyzed. The relatively high frequency of neu amplification points to a functional role in human breast cancer. Coamplification of the c-erbA oncogene could contribute to this disease as well but is most likely fortuitous
AB - We investigated alterations in the structure and expression of oncogenes in mammary tumors and mammary tumor-derived cell lines. In 16 of 95 samples, we detected amplification of the human neu oncogene, also known as c-erB-2, accompanied by overexpression in the tumors from which intact RNA could be isolated. In 10 of these DNAs, the linked oncogene c-erbA was also amplified, whereas another gene on human chromosome 17, p53, was present in normal copy numbers. Overexpression of c-erbA could not be detected in the tumors analyzed. The relatively high frequency of neu amplification points to a functional role in human breast cancer. Coamplification of the c-erbA oncogene could contribute to this disease as well but is most likely fortuitous
U2 - https://doi.org/10.1128/MCB.7.5.2019
DO - https://doi.org/10.1128/MCB.7.5.2019
M3 - Comment/Letter to the editor
C2 - 3299059
SN - 0270-7306
VL - 7
SP - 2019
EP - 2023
JO - Molecular and Cellular Biology
JF - Molecular and Cellular Biology
IS - 5
ER -