Amsterdam Acute Aneurysm Trial: Background, design, and methods

L. L. Hoornweg; Ron Balm; D. A. Legemate; M. M. Idu; C. Kox; J. A. Reekers; K. P. Van Lienden; O. M. Van Delden; W. Wisselink; J. A. Rauwerda; F. G. Van Den Berg; A. C. Vahl; M. J.T. Visser; F. H.W.M. Van Der Heijden; C. De Vries; V. P.M. Van Der Hulst; A. D. Montauban Van Swijndregt; T. O.M. Nagy; A. M. Wiersema; A. Voorwinde; J. A. Lawson; Th A.A. Van Der Broek; R. A. Cohen; D. Nio; J. P. Tijssen; B. A.J.M. De Mol; B. C. Eikelboom

doi:https://doi.org/10.2310/6670.2006.00027

Amsterdam Acute Aneurysm Trial: Background, design, and methods

L. L. Hoornweg, Ron Balm, D. A. Legemate, M. M. Idu, C. Kox, J. A. Reekers, K. P. Van Lienden, O. M. Van Delden, W. Wisselink, J. A. Rauwerda, F. G. Van Den Berg, A. C. Vahl, M. J.T. Visser, F. H.W.M. Van Der Heijden, C. De Vries, V. P.M. Van Der Hulst, A. D. Montauban Van Swijndregt, T. O.M. Nagy, A. M. Wiersema, A. VoorwindeJ. A. Lawson, Th A.A. Van Der Broek, R. A. Cohen, D. Nio, J. P. Tijssen, B. A.J.M. De Mol, B. C. Eikelboom

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The objective of the Amsterdam Acute Aneurysm Trial is to study the combined outcome of conventional emergency surgery versus endovascular treatment for ruptured abdominal aortic aneurysms. The design used was a multicenter randomized clinical trial conducted in two university hospitals and one teaching hospital in the Amsterdam region. The study included all patients with a ruptured abdominal aneurysm who were eligible for endovascular and conventional surgery. The primary end points were combined mortality and severe morbidity. The secondary end points were quality of life and cost-effectiveness. The background, design, and methods of this trial are presented, and the ethical and legal issues of this type of research are discussed.

Original language	English
Pages (from-to)	130-135
Number of pages	6
Journal	Vascular
Volume	14
Issue number	3
DOIs	https://doi.org/10.2310/6670.2006.00027
Publication status	Published - May 2006

Keywords

Endovascular repair
Ethics
Legal issues
Mortality
Randomized controlled trial
Research design
Ruptured aortic aneurysms

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Hoornweg, L. L., Balm, R., Legemate, D. A., Idu, M. M., Kox, C., Reekers, J. A., Van Lienden, K. P., Van Delden, O. M., Wisselink, W., Rauwerda, J. A., Van Den Berg, F. G., Vahl, A. C., Visser, M. J. T., Van Der Heijden, F. H. W. M., De Vries, C., Van Der Hulst, V. P. M., Montauban Van Swijndregt, A. D., Nagy, T. O. M., Wiersema, A. M., ... Eikelboom, B. C. (2006). Amsterdam Acute Aneurysm Trial: Background, design, and methods. Vascular, 14(3), 130-135. https://doi.org/10.2310/6670.2006.00027

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abstract = "The objective of the Amsterdam Acute Aneurysm Trial is to study the combined outcome of conventional emergency surgery versus endovascular treatment for ruptured abdominal aortic aneurysms. The design used was a multicenter randomized clinical trial conducted in two university hospitals and one teaching hospital in the Amsterdam region. The study included all patients with a ruptured abdominal aneurysm who were eligible for endovascular and conventional surgery. The primary end points were combined mortality and severe morbidity. The secondary end points were quality of life and cost-effectiveness. The background, design, and methods of this trial are presented, and the ethical and legal issues of this type of research are discussed.",

keywords = "Endovascular repair, Ethics, Legal issues, Mortality, Randomized controlled trial, Research design, Ruptured aortic aneurysms",

author = "Hoornweg, {L. L.} and Ron Balm and Legemate, {D. A.} and Idu, {M. M.} and C. Kox and Reekers, {J. A.} and {Van Lienden}, {K. P.} and {Van Delden}, {O. M.} and W. Wisselink and Rauwerda, {J. A.} and {Van Den Berg}, {F. G.} and Vahl, {A. C.} and Visser, {M. J.T.} and {Van Der Heijden}, {F. H.W.M.} and {De Vries}, C. and {Van Der Hulst}, {V. P.M.} and {Montauban Van Swijndregt}, {A. D.} and Nagy, {T. O.M.} and Wiersema, {A. M.} and A. Voorwinde and Lawson, {J. A.} and {Van Der Broek}, {Th A.A.} and Cohen, {R. A.} and D. Nio and Tijssen, {J. P.} and {De Mol}, {B. A.J.M.} and Eikelboom, {B. C.}",

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Hoornweg, LL, Balm, R, Legemate, DA , Idu, MM, Kox, C, Reekers, JA, Van Lienden, KP, Van Delden, OM, Wisselink, W , Rauwerda, JA, Van Den Berg, FG, Vahl, AC, Visser, MJT, Van Der Heijden, FHWM, De Vries, C, Van Der Hulst, VPM, Montauban Van Swijndregt, AD, Nagy, TOM, Wiersema, AM, Voorwinde, A, Lawson, JA, Van Der Broek, TAA, Cohen, RA, Nio, D, Tijssen, JP, De Mol, BAJM & Eikelboom, BC 2006, 'Amsterdam Acute Aneurysm Trial: Background, design, and methods', Vascular, vol. 14, no. 3, pp. 130-135. https://doi.org/10.2310/6670.2006.00027

TY - JOUR

T1 - Amsterdam Acute Aneurysm Trial

T2 - Background, design, and methods

AU - Hoornweg, L. L.

AU - Balm, Ron

AU - Legemate, D. A.

AU - Idu, M. M.

AU - Kox, C.

AU - Reekers, J. A.

AU - Van Lienden, K. P.

AU - Van Delden, O. M.

AU - Wisselink, W.

AU - Rauwerda, J. A.

AU - Van Den Berg, F. G.

AU - Vahl, A. C.

AU - Visser, M. J.T.

AU - Van Der Heijden, F. H.W.M.

AU - De Vries, C.

AU - Van Der Hulst, V. P.M.

AU - Montauban Van Swijndregt, A. D.

AU - Nagy, T. O.M.

AU - Wiersema, A. M.

AU - Voorwinde, A.

AU - Lawson, J. A.

AU - Van Der Broek, Th A.A.

AU - Cohen, R. A.

AU - Nio, D.

AU - Tijssen, J. P.

AU - De Mol, B. A.J.M.

AU - Eikelboom, B. C.

PY - 2006/5

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N2 - The objective of the Amsterdam Acute Aneurysm Trial is to study the combined outcome of conventional emergency surgery versus endovascular treatment for ruptured abdominal aortic aneurysms. The design used was a multicenter randomized clinical trial conducted in two university hospitals and one teaching hospital in the Amsterdam region. The study included all patients with a ruptured abdominal aneurysm who were eligible for endovascular and conventional surgery. The primary end points were combined mortality and severe morbidity. The secondary end points were quality of life and cost-effectiveness. The background, design, and methods of this trial are presented, and the ethical and legal issues of this type of research are discussed.

AB - The objective of the Amsterdam Acute Aneurysm Trial is to study the combined outcome of conventional emergency surgery versus endovascular treatment for ruptured abdominal aortic aneurysms. The design used was a multicenter randomized clinical trial conducted in two university hospitals and one teaching hospital in the Amsterdam region. The study included all patients with a ruptured abdominal aneurysm who were eligible for endovascular and conventional surgery. The primary end points were combined mortality and severe morbidity. The secondary end points were quality of life and cost-effectiveness. The background, design, and methods of this trial are presented, and the ethical and legal issues of this type of research are discussed.

KW - Endovascular repair

KW - Ethics

KW - Legal issues

KW - Mortality

KW - Randomized controlled trial

KW - Research design

KW - Ruptured aortic aneurysms

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DO - https://doi.org/10.2310/6670.2006.00027

M3 - Article

C2 - 16956484

SN - 1708-5381

VL - 14

SP - 130

EP - 135

JO - Vascular

JF - Vascular

IS - 3

ER -

Amsterdam Acute Aneurysm Trial: Background, design, and methods

Abstract

Keywords

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