TY - JOUR
T1 - An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles
AU - Wilson, A. G.
AU - de Vries, N. [=Niek]
AU - Pociot, F.
AU - di Giovine, F. S.
AU - van der Putte, L. B.
AU - Duff, G. W.
PY - 1993
Y1 - 1993
N2 - The tumor necrosis factor (TNF) alpha gene lies within the class III region of the major histocompatibility complex (MHC), telomeric to the class II and centromeric to the class I region. We have recently described the first polymorphism within the human TNF-alpha locus. This is biallelic and lies within the promoter region. Frequency analysis of the TNF-alpha polymorphism, using the polymerase chain reaction and single-stranded conformational polymorphism, in HLA-typed individuals, reveals a very strong association between the uncommon TNF allele and HLA A1, B8, and DR3 alleles. This is the first association between TNF-alpha and other MHC alleles and raises the possibility that the uncommon TNF-alpha allele may contribute to the many autoimmune associations of the A1,B8,DR3 haplotype
AB - The tumor necrosis factor (TNF) alpha gene lies within the class III region of the major histocompatibility complex (MHC), telomeric to the class II and centromeric to the class I region. We have recently described the first polymorphism within the human TNF-alpha locus. This is biallelic and lies within the promoter region. Frequency analysis of the TNF-alpha polymorphism, using the polymerase chain reaction and single-stranded conformational polymorphism, in HLA-typed individuals, reveals a very strong association between the uncommon TNF allele and HLA A1, B8, and DR3 alleles. This is the first association between TNF-alpha and other MHC alleles and raises the possibility that the uncommon TNF-alpha allele may contribute to the many autoimmune associations of the A1,B8,DR3 haplotype
U2 - https://doi.org/10.1084/jem.177.2.557
DO - https://doi.org/10.1084/jem.177.2.557
M3 - Comment/Letter to the editor
C2 - 8426126
SN - 0022-1007
VL - 177
SP - 557
EP - 560
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 2
ER -