TY - JOUR
T1 - An ApoA-I mimetic peptide high-density-lipoprotein-based MRI contrast agent for atherosclerotic plaque composition detection
AU - Cormode, David P.
AU - Briley-Saebo, Karen C.
AU - Mulder, Willem J. M.
AU - Aguinaldo, Juan Gilberto S.
AU - Barazza, Alessandra
AU - Ma, Yanqing
AU - Fisher, Edward A.
AU - Fayad, Zahi A.
PY - 2008
Y1 - 2008
N2 - Cardiovascular disease is one of the prime causes of mortality throughout the world and there is a need for targeted and effective contrast agents to allow noninvasive imaging of the cholesterol-rich atherosclerotic plaques in arteries. A new, fully synthetic, high-density lipoprotein (HDL)-mimicking MRI contrast agent is developed, which enhances macrophage-rich areas of plaque in a mouse model of atherosclerosis by 94%. Confirmation of the targeting of this nanoparticulate agent is achieved using confocal microscopy by tracking a fluorescent lipid incorporated into the nanoparticle
AB - Cardiovascular disease is one of the prime causes of mortality throughout the world and there is a need for targeted and effective contrast agents to allow noninvasive imaging of the cholesterol-rich atherosclerotic plaques in arteries. A new, fully synthetic, high-density lipoprotein (HDL)-mimicking MRI contrast agent is developed, which enhances macrophage-rich areas of plaque in a mouse model of atherosclerosis by 94%. Confirmation of the targeting of this nanoparticulate agent is achieved using confocal microscopy by tracking a fluorescent lipid incorporated into the nanoparticle
U2 - https://doi.org/10.1002/smll.200701285
DO - https://doi.org/10.1002/smll.200701285
M3 - Article
C2 - 18712752
SN - 1613-6810
VL - 4
SP - 1437
EP - 1444
JO - Small (Weinheim an der Bergstrasse, Germany)
JF - Small (Weinheim an der Bergstrasse, Germany)
IS - 9
ER -