TY - JOUR
T1 - An electronic nose distinguishes exhaled breath of patients with Malignant Pleural Mesothelioma from controls
AU - Dragonieri, Silvano
AU - van der Schee, Marc P.
AU - Massaro, Tommaso
AU - Schiavulli, Nunzia
AU - Brinkman, Paul
AU - Pinca, Armando
AU - Carratú, Pierluigi
AU - Spanevello, Antonio
AU - Resta, Onofrio
AU - Musti, Marina
AU - Sterk, Peter J.
PY - 2012
Y1 - 2012
N2 - Background: Malignant Pleural Mesothelioma (MPM) is a tumour of the surface cells of the pleura that is highly aggressive and mainly caused by asbestos exposure. Electronic noses capture the spectrum of exhaled volatile organic compounds (VOCs) providing a composite biomarker profile (breathprint). Objective: We tested the hypothesis that an electronic nose can discriminate exhaled air of patients with,MPM from subjects with a similar long-term professional exposure to asbestos without MPM and from healthy controls. Methods: 13 patients with a histology confirmed diagnosis of MPM (age 60.9 +/- 12.2 year), 13 subjects with certified, long-term professional asbestos exposure (age 67.2 +/- 9.8), and 13 healthy subjects without asbestos exposure (age 52.2 +/- 16.2) participated in a cross-sectional study. Exhaled breath was collected by a previously described method and sampled by an electronic nose (Cyranose 320). Breathprints were analyzed by canonical discriminant analysis on principal component reduction. Cross-validated accuracy (CVA) was calculated. Results: Breathprints from patients with MPM were separated from subjects with asbestos exposure (CVA: 80.8%, sensitivity 92.3%, specificity 85.7%). MPM was also distinguished from healthy controls (CVA: 84.6%). Repeated measurements confirmed these results. Conclusions: Molecular pattern recognition of exhaled breath can correctly distinguish patients with MPM from subjects with similar occupational asbestos exposure without MPM and from healthy controls. This suggests that breathprints obtained by electronic nose have diagnostic potential for MPM. (C) 2011 Elsevier Ireland Ltd. All rights reserved
AB - Background: Malignant Pleural Mesothelioma (MPM) is a tumour of the surface cells of the pleura that is highly aggressive and mainly caused by asbestos exposure. Electronic noses capture the spectrum of exhaled volatile organic compounds (VOCs) providing a composite biomarker profile (breathprint). Objective: We tested the hypothesis that an electronic nose can discriminate exhaled air of patients with,MPM from subjects with a similar long-term professional exposure to asbestos without MPM and from healthy controls. Methods: 13 patients with a histology confirmed diagnosis of MPM (age 60.9 +/- 12.2 year), 13 subjects with certified, long-term professional asbestos exposure (age 67.2 +/- 9.8), and 13 healthy subjects without asbestos exposure (age 52.2 +/- 16.2) participated in a cross-sectional study. Exhaled breath was collected by a previously described method and sampled by an electronic nose (Cyranose 320). Breathprints were analyzed by canonical discriminant analysis on principal component reduction. Cross-validated accuracy (CVA) was calculated. Results: Breathprints from patients with MPM were separated from subjects with asbestos exposure (CVA: 80.8%, sensitivity 92.3%, specificity 85.7%). MPM was also distinguished from healthy controls (CVA: 84.6%). Repeated measurements confirmed these results. Conclusions: Molecular pattern recognition of exhaled breath can correctly distinguish patients with MPM from subjects with similar occupational asbestos exposure without MPM and from healthy controls. This suggests that breathprints obtained by electronic nose have diagnostic potential for MPM. (C) 2011 Elsevier Ireland Ltd. All rights reserved
U2 - https://doi.org/10.1016/j.lungcan.2011.08.009
DO - https://doi.org/10.1016/j.lungcan.2011.08.009
M3 - Article
C2 - 21924516
SN - 0169-5002
VL - 75
SP - 326
EP - 331
JO - Lung cancer (Amsterdam, Netherlands)
JF - Lung cancer (Amsterdam, Netherlands)
IS - 3
ER -