TY - JOUR
T1 - An Experimenter's Guide to Glioblastoma Invasion Pathways
AU - de Gooijer, Mark C.
AU - Guillén Navarro, Miriam
AU - Bernards, Rene
AU - Wurdinger, Thomas
AU - van Tellingen, Olaf
PY - 2018
Y1 - 2018
N2 - Glioblastoma is a highly aggressive brain tumor that is characterized by its unparalleled invasiveness. Invasive glioblastoma cells not only escape surgery and focal therapies but also are more resistant to current radio- and chemo-therapeutic approaches. Thus, any curative therapy for this deadly disease likely should include treatment strategies that interfere with glioblastoma invasiveness. Understanding glioblastoma invasion mechanisms is therefore critical. We discuss the strengths and weaknesses of various glioblastoma invasion models and conclude that robust experimental evidence has been obtained for a pro-invasive role of Ephrin receptors, Rho GTPases, and casein kinase 2 (CK2). Extensive interplay occurs between these proteins, suggesting the existence of a glioblastoma invasion signaling network that comprises several targets for therapy.
AB - Glioblastoma is a highly aggressive brain tumor that is characterized by its unparalleled invasiveness. Invasive glioblastoma cells not only escape surgery and focal therapies but also are more resistant to current radio- and chemo-therapeutic approaches. Thus, any curative therapy for this deadly disease likely should include treatment strategies that interfere with glioblastoma invasiveness. Understanding glioblastoma invasion mechanisms is therefore critical. We discuss the strengths and weaknesses of various glioblastoma invasion models and conclude that robust experimental evidence has been obtained for a pro-invasive role of Ephrin receptors, Rho GTPases, and casein kinase 2 (CK2). Extensive interplay occurs between these proteins, suggesting the existence of a glioblastoma invasion signaling network that comprises several targets for therapy.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85050692941&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30072121
U2 - https://doi.org/10.1016/j.molmed.2018.07.003
DO - https://doi.org/10.1016/j.molmed.2018.07.003
M3 - Review article
C2 - 30072121
SN - 1471-4914
VL - 24
SP - 763
EP - 780
JO - Trends in molecular medicine
JF - Trends in molecular medicine
IS - 9
ER -