An immunohistochemical study on cerebral vascular and senile plaque amyloid in Alzheimer's dementia

P. Eikelenboom; F. C. Stam

doi:https://doi.org/10.1007/BF02890185

An immunohistochemical study on cerebral vascular and senile plaque amyloid in Alzheimer's dementia

P. Eikelenboom, F. C. Stam

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72 Citations (Scopus)

Abstract

Senile cerebral amyloidosis has been investigated using immunoperoxidase and enzyme histochemical techniques in six unfixed brains. Our findings do not support the opinion that vascular and senile plaque amyloid are immunoglobulin-derived. In contrast with recent reports we did not detect prealbumin in senile plaques and congophilic angiopathy lesions. All senile plaques contain complement factors C1q, C3 and C4. The highest peroxidase activity was found in the amyloid nucleus but the corona also showed evident peroxidase activity

Original language	English
Pages (from-to)	17-25
Journal	Virchows Archiv. B, Cell pathology including molecular pathology
Volume	47
Issue number	1
DOIs	https://doi.org/10.1007/BF02890185
Publication status	Published - 1984

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https://doi.org/10.1007/BF02890185

Cite this

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title = "An immunohistochemical study on cerebral vascular and senile plaque amyloid in Alzheimer's dementia",

abstract = "Senile cerebral amyloidosis has been investigated using immunoperoxidase and enzyme histochemical techniques in six unfixed brains. Our findings do not support the opinion that vascular and senile plaque amyloid are immunoglobulin-derived. In contrast with recent reports we did not detect prealbumin in senile plaques and congophilic angiopathy lesions. All senile plaques contain complement factors C1q, C3 and C4. The highest peroxidase activity was found in the amyloid nucleus but the corona also showed evident peroxidase activity",

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AU - Eikelenboom, P.

AU - Stam, F. C.

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AB - Senile cerebral amyloidosis has been investigated using immunoperoxidase and enzyme histochemical techniques in six unfixed brains. Our findings do not support the opinion that vascular and senile plaque amyloid are immunoglobulin-derived. In contrast with recent reports we did not detect prealbumin in senile plaques and congophilic angiopathy lesions. All senile plaques contain complement factors C1q, C3 and C4. The highest peroxidase activity was found in the amyloid nucleus but the corona also showed evident peroxidase activity

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DO - https://doi.org/10.1007/BF02890185

M3 - Article

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JO - Virchows Archiv. B, Cell pathology including molecular pathology

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