An integrated physical map of 210 markers assigned to the short arm of human chromosome 11

E. Redeker; J. M. Hoovers; M. Alders; C. J. van Moorsel; A. C. Ivens; S. Gregory; L. Kalikin; J. Bliek; L. de Galan; R. van den Bogaard; J. Visser; R. van der Voort; A. P. Feinberg; P. F. R. Little; A. Westerveld; M. Mannens

doi:https://doi.org/10.1006/geno.1994.1312

An integrated physical map of 210 markers assigned to the short arm of human chromosome 11

E. Redeker, J. M. Hoovers, M. Alders, C. J. van Moorsel, A. C. Ivens, S. Gregory, L. Kalikin, J. Bliek, L. de Galan, R. van den Bogaard, J. Visser, R. van der Voort, A. P. Feinberg, P. F. R. Little, A. Westerveld, M. Mannens

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Research output: Contribution to journal › Article › Academic › peer-review

28 Citations (Scopus)

Abstract

Using a panel of patient cell lines with chromosomal breakpoints, we constructed a physical map for the short arm of human chromosome 11. We focused on 11p15, a chromosome band harboring at least 25 known genes and associated with the Beckwith-Wiedemann syndrome, several childhood tumors, and genomic imprinting. This underlines the need for a physical map for this region. We divided the short arm of chromosome 11 into 18 breakpoint regions, and a large series of new and previously described genes and markers was mapped within these intervals using fluorescence in situ hybridization. Cosmid fingerprint analysis showed that 19 of these markers were included in cosmid contigs. A detailed 10-Mb pulsed-field physical map of the region 11p15.3-pter was constructed. These three different approaches enabled the high-resolution mapping of 210 markers, including 22 known genes

Original language	English
Pages (from-to)	538-550
Journal	Genomics
Volume	21
Issue number	3
DOIs	https://doi.org/10.1006/geno.1994.1312
Publication status	Published - 1994

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https://doi.org/10.1006/geno.1994.1312

Cite this

Redeker, E., Hoovers, J. M., Alders, M., van Moorsel, C. J., Ivens, A. C., Gregory, S., Kalikin, L., Bliek, J., de Galan, L., van den Bogaard, R., Visser, J., van der Voort, R., Feinberg, A. P., Little, P. F. R., Westerveld, A., & Mannens, M. (1994). An integrated physical map of 210 markers assigned to the short arm of human chromosome 11. Genomics, 21(3), 538-550. https://doi.org/10.1006/geno.1994.1312

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title = "An integrated physical map of 210 markers assigned to the short arm of human chromosome 11",

abstract = "Using a panel of patient cell lines with chromosomal breakpoints, we constructed a physical map for the short arm of human chromosome 11. We focused on 11p15, a chromosome band harboring at least 25 known genes and associated with the Beckwith-Wiedemann syndrome, several childhood tumors, and genomic imprinting. This underlines the need for a physical map for this region. We divided the short arm of chromosome 11 into 18 breakpoint regions, and a large series of new and previously described genes and markers was mapped within these intervals using fluorescence in situ hybridization. Cosmid fingerprint analysis showed that 19 of these markers were included in cosmid contigs. A detailed 10-Mb pulsed-field physical map of the region 11p15.3-pter was constructed. These three different approaches enabled the high-resolution mapping of 210 markers, including 22 known genes",

author = "E. Redeker and Hoovers, {J. M.} and M. Alders and {van Moorsel}, {C. J.} and Ivens, {A. C.} and S. Gregory and L. Kalikin and J. Bliek and {de Galan}, L. and {van den Bogaard}, R. and J. Visser and {van der Voort}, R. and Feinberg, {A. P.} and Little, {P. F. R.} and A. Westerveld and M. Mannens",

year = "1994",

doi = "https://doi.org/10.1006/geno.1994.1312",

language = "English",

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pages = "538--550",

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Redeker, E, Hoovers, JM, Alders, M, van Moorsel, CJ, Ivens, AC, Gregory, S, Kalikin, L, Bliek, J, de Galan, L, van den Bogaard, R, Visser, J, van der Voort, R, Feinberg, AP, Little, PFR, Westerveld, A & Mannens, M 1994, 'An integrated physical map of 210 markers assigned to the short arm of human chromosome 11', Genomics, vol. 21, no. 3, pp. 538-550. https://doi.org/10.1006/geno.1994.1312

TY - JOUR

T1 - An integrated physical map of 210 markers assigned to the short arm of human chromosome 11

AU - Redeker, E.

AU - Hoovers, J. M.

AU - Alders, M.

AU - van Moorsel, C. J.

AU - Ivens, A. C.

AU - Gregory, S.

AU - Kalikin, L.

AU - Bliek, J.

AU - de Galan, L.

AU - van den Bogaard, R.

AU - Visser, J.

AU - van der Voort, R.

AU - Feinberg, A. P.

AU - Little, P. F. R.

AU - Westerveld, A.

AU - Mannens, M.

PY - 1994

Y1 - 1994

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AB - Using a panel of patient cell lines with chromosomal breakpoints, we constructed a physical map for the short arm of human chromosome 11. We focused on 11p15, a chromosome band harboring at least 25 known genes and associated with the Beckwith-Wiedemann syndrome, several childhood tumors, and genomic imprinting. This underlines the need for a physical map for this region. We divided the short arm of chromosome 11 into 18 breakpoint regions, and a large series of new and previously described genes and markers was mapped within these intervals using fluorescence in situ hybridization. Cosmid fingerprint analysis showed that 19 of these markers were included in cosmid contigs. A detailed 10-Mb pulsed-field physical map of the region 11p15.3-pter was constructed. These three different approaches enabled the high-resolution mapping of 210 markers, including 22 known genes

U2 - https://doi.org/10.1006/geno.1994.1312

DO - https://doi.org/10.1006/geno.1994.1312

M3 - Article

C2 - 7959730

SN - 0888-7543

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SP - 538

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JO - Genomics

JF - Genomics

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