An interactive three-dimensional digital atlas and quantitative database of human development

Bernadette S. de Bakker; Kees H. de Jong; Jaco Hagoort; Karel de Bree; Clara T. Besselink; Froukje E. C. de Kanter; Tyas Veldhuis; Babette Bais; Reggie Schildmeijer; Jan M. Ruijter; Roelof-Jan Oostra; Vincent M. Christoffels; Antoon F. M. Moorman

doi:https://doi.org/10.1126/science.aag0053

An interactive three-dimensional digital atlas and quantitative database of human development

Bernadette S. de Bakker, Kees H. de Jong, Jaco Hagoort, Karel de Bree, Clara T. Besselink, Froukje E. C. de Kanter, Tyas Veldhuis, Babette Bais, Reggie Schildmeijer, Jan M. Ruijter, Roelof-Jan Oostra, Vincent M. Christoffels, Antoon F. M. Moorman

Research output: Contribution to journal › Article › Academic › peer-review

141 Citations (Scopus)

Abstract

Current knowledge about human development is based on the description of a limited number of embryonic specimens published in original articles and textbooks, often more than 100 years ago. It is exceedingly difficult to verify this knowledge, given the restricted availability of human embryos. We created a three-dimensional digital atlas and database spanning the first 2 months of human development, based on analysis of nearly 15,000 histological sections of the renowned Carnegie Collection of human embryonic specimens. We identified and labeled up to 150 organs and structures per specimen and made three-dimensional models to quantify growth, establish changes in the position of organs, and clarify current ambiguities. The atlas provides an educational and reference resource for studies on early human development, growth, and congenital malformations

Original language	English
Pages (from-to)	1019 aag0053-+
Journal	Science
Volume	354
Issue number	6315
Early online date	2016
DOIs	https://doi.org/10.1126/science.aag0053
Publication status	Published - 2016

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https://doi.org/10.1126/science.aag0053

Cite this

de Bakker, B. S., de Jong, K. H., Hagoort, J., de Bree, K., Besselink, C. T., de Kanter, F. E. C., Veldhuis, T., Bais, B., Schildmeijer, R., Ruijter, J. M., Oostra, R.-J., Christoffels, V. M., & Moorman, A. F. M. (2016). An interactive three-dimensional digital atlas and quantitative database of human development. Science, 354(6315), 1019 aag0053-+. https://doi.org/10.1126/science.aag0053

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title = "An interactive three-dimensional digital atlas and quantitative database of human development",

abstract = "Current knowledge about human development is based on the description of a limited number of embryonic specimens published in original articles and textbooks, often more than 100 years ago. It is exceedingly difficult to verify this knowledge, given the restricted availability of human embryos. We created a three-dimensional digital atlas and database spanning the first 2 months of human development, based on analysis of nearly 15,000 histological sections of the renowned Carnegie Collection of human embryonic specimens. We identified and labeled up to 150 organs and structures per specimen and made three-dimensional models to quantify growth, establish changes in the position of organs, and clarify current ambiguities. The atlas provides an educational and reference resource for studies on early human development, growth, and congenital malformations",

author = "{de Bakker}, {Bernadette S.} and {de Jong}, {Kees H.} and Jaco Hagoort and {de Bree}, Karel and Besselink, {Clara T.} and {de Kanter}, {Froukje E. C.} and Tyas Veldhuis and Babette Bais and Reggie Schildmeijer and Ruijter, {Jan M.} and Roelof-Jan Oostra and Christoffels, {Vincent M.} and Moorman, {Antoon F. M.}",

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de Bakker, BS, de Jong, KH, Hagoort, J, de Bree, K, Besselink, CT, de Kanter, FEC, Veldhuis, T, Bais, B, Schildmeijer, R, Ruijter, JM , Oostra, R-J , Christoffels, VM & Moorman, AFM 2016, 'An interactive three-dimensional digital atlas and quantitative database of human development', Science, vol. 354, no. 6315, pp. 1019 aag0053-+. https://doi.org/10.1126/science.aag0053

TY - JOUR

T1 - An interactive three-dimensional digital atlas and quantitative database of human development

AU - de Bakker, Bernadette S.

AU - de Jong, Kees H.

AU - Hagoort, Jaco

AU - de Bree, Karel

AU - Besselink, Clara T.

AU - de Kanter, Froukje E. C.

AU - Veldhuis, Tyas

AU - Bais, Babette

AU - Schildmeijer, Reggie

AU - Ruijter, Jan M.

AU - Oostra, Roelof-Jan

AU - Christoffels, Vincent M.

AU - Moorman, Antoon F. M.

PY - 2016

Y1 - 2016

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