An overview of robotic capsules for drug delivery to the gastrointestinal tract

Pablo Cortegoso Valdivia; Alexander R. Robertson; Nanne K. H. de Boer; Wojciech Marlicz; Anastasios Koulaouzidis

doi:https://doi.org/10.3390/jcm10245791

An overview of robotic capsules for drug delivery to the gastrointestinal tract

Pablo Cortegoso Valdivia, Alexander R. Robertson, Nanne K. H. de Boer, Wojciech Marlicz, Anastasios Koulaouzidis

Research output: Contribution to journal › Review article › Academic › peer-review

15 Citations (Scopus)

Abstract

The introduction of capsule endoscopy two decades ago marked the beginning of the “small bowel revolution”. Since then, the rapid evolution of microtechnology has allowed the development of drug delivery systems (DDS) designed to address some of the needs that are not met by standard drug delivery. To overcome the complex anatomy and physiology of the gastrointestinal (GI) tract, several DDS have been developed, including many prototypes being designed, built and eventually produced with ingenious drug‐release mechanisms and anchoring systems allowing targeted therapy. This review highlights the currently available systems for drug delivery in the GI tract and discusses the needs, limitations, and future considerations of these technologies.

Original language	English
Article number	5791
Journal	Clinical Chemistry
Volume	10
Issue number	24
DOIs	https://doi.org/10.3390/jcm10245791
Publication status	Published - 1 Dec 2021

Keywords

Capsule
Capsule endoscopy
Delivery
Digestive
Drug
Gastrointestinal
Innovation
Technology

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title = "An overview of robotic capsules for drug delivery to the gastrointestinal tract",

abstract = "The introduction of capsule endoscopy two decades ago marked the beginning of the “small bowel revolution”. Since then, the rapid evolution of microtechnology has allowed the development of drug delivery systems (DDS) designed to address some of the needs that are not met by standard drug delivery. To overcome the complex anatomy and physiology of the gastrointestinal (GI) tract, several DDS have been developed, including many prototypes being designed, built and eventually produced with ingenious drug‐release mechanisms and anchoring systems allowing targeted therapy. This review highlights the currently available systems for drug delivery in the GI tract and discusses the needs, limitations, and future considerations of these technologies.",

keywords = "Capsule, Capsule endoscopy, Delivery, Digestive, Drug, Gastrointestinal, Innovation, Technology",

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AU - Marlicz, Wojciech

AU - Koulaouzidis, Anastasios

N1 - Funding Information: This work has been supported/funded (in part) by the EU?Next?generation EU (ID SEED/0719/0084). Funding Information: Funding: This work has been supported/funded (in part) by the EU–Next‐generation EU (ID SEED/0719/0084). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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N2 - The introduction of capsule endoscopy two decades ago marked the beginning of the “small bowel revolution”. Since then, the rapid evolution of microtechnology has allowed the development of drug delivery systems (DDS) designed to address some of the needs that are not met by standard drug delivery. To overcome the complex anatomy and physiology of the gastrointestinal (GI) tract, several DDS have been developed, including many prototypes being designed, built and eventually produced with ingenious drug‐release mechanisms and anchoring systems allowing targeted therapy. This review highlights the currently available systems for drug delivery in the GI tract and discusses the needs, limitations, and future considerations of these technologies.

AB - The introduction of capsule endoscopy two decades ago marked the beginning of the “small bowel revolution”. Since then, the rapid evolution of microtechnology has allowed the development of drug delivery systems (DDS) designed to address some of the needs that are not met by standard drug delivery. To overcome the complex anatomy and physiology of the gastrointestinal (GI) tract, several DDS have been developed, including many prototypes being designed, built and eventually produced with ingenious drug‐release mechanisms and anchoring systems allowing targeted therapy. This review highlights the currently available systems for drug delivery in the GI tract and discusses the needs, limitations, and future considerations of these technologies.

KW - Capsule

KW - Capsule endoscopy

KW - Delivery

KW - Digestive

KW - Drug

KW - Gastrointestinal

KW - Innovation

KW - Technology

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VL - 10

JO - Clinical Chemistry

JF - Clinical Chemistry

IS - 24

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ER -

An overview of robotic capsules for drug delivery to the gastrointestinal tract

Abstract

Keywords

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