TY - JOUR
T1 - An Overview of Three Promising Mechanical, Optical, and Biochemical Engineering Approaches to Improve Selective Photothermolysis of Refractory Port Wine Stains
AU - Aguilar, Guillermo
AU - Choi, Bernard
AU - Broekgaarden, Mans
AU - Yang, Owen
AU - Yang, Bruce
AU - Ghasri, Pedram
AU - Chen, Jennifer K.
AU - Bezemer, Rick
AU - Nelson, J. Stuart
AU - van Drooge, Anne Margreet
AU - Wolkerstorfer, Albert
AU - Kelly, Kristen M.
AU - Heger, Michal
PY - 2012
Y1 - 2012
N2 - During the last three decades, several laser systems, ancillary technologies, and treatment modalities have been developed for the treatment of port wine stains (PWSs). However, approximately half of the PWS patient population responds suboptimally to laser treatment. Consequently, novel treatment modalities and therapeutic techniques/strategies are required to improve PWS treatment efficacy. This overview therefore focuses on three distinct experimental approaches for the optimization of PWS laser treatment. The approaches are addressed from the perspective of mechanical engineering (the use of local hypobaric pressure to induce vasodilation in the laser-irradiated dermal microcirculation), optical engineering (laser-speckle imaging of post-treatment flow in laser-treated PWS skin), and biochemical engineering (light- and heat-activatable liposomal drug delivery systems to enhance the extent of post-irradiation vascular occlusion)
AB - During the last three decades, several laser systems, ancillary technologies, and treatment modalities have been developed for the treatment of port wine stains (PWSs). However, approximately half of the PWS patient population responds suboptimally to laser treatment. Consequently, novel treatment modalities and therapeutic techniques/strategies are required to improve PWS treatment efficacy. This overview therefore focuses on three distinct experimental approaches for the optimization of PWS laser treatment. The approaches are addressed from the perspective of mechanical engineering (the use of local hypobaric pressure to induce vasodilation in the laser-irradiated dermal microcirculation), optical engineering (laser-speckle imaging of post-treatment flow in laser-treated PWS skin), and biochemical engineering (light- and heat-activatable liposomal drug delivery systems to enhance the extent of post-irradiation vascular occlusion)
U2 - https://doi.org/10.1007/s10439-011-0436-9
DO - https://doi.org/10.1007/s10439-011-0436-9
M3 - Article
C2 - 22016324
SN - 0090-6964
VL - 40
SP - 486
EP - 506
JO - Annals of biomedical engineering
JF - Annals of biomedical engineering
IS - 2
ER -