TY - JOUR
T1 - Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones.
AU - Bayley, J.P.
AU - Bakker, AM
AU - Kaijzel, EL
AU - Wierenga, EA
AU - van der Pouw Kraan, C.T.M.
AU - Huizinga, T.W.
AU - Verweij, C.L.
AU - Bakker, Aleida M.
AU - Kaijzel, Eric L.
AU - Wierenga, Eddy A.
PY - 2003
Y1 - 2003
N2 - The occurrence of monoallelic expression of cytokine genes in single cells has been convincingly demonstrated, but there have been few reports of this phenomenon in T cell clones. Here we describe studies on the expression of alleles of the human genes encoding IL-2, IL-3, IL-4, and IL-13 in human CD4(+) T cell clones. In contrast to the results reported in mouse T cell clones and single human T cells, we found no evidence for the monoallelic expression of the IL-2, IL-3, and IL-13 genes. The gene for IL-4 showed an imbalance in expression from each allele, indicating differential expression of IL-4 alleles within or between IL-4-expressing cells
AB - The occurrence of monoallelic expression of cytokine genes in single cells has been convincingly demonstrated, but there have been few reports of this phenomenon in T cell clones. Here we describe studies on the expression of alleles of the human genes encoding IL-2, IL-3, IL-4, and IL-13 in human CD4(+) T cell clones. In contrast to the results reported in mouse T cell clones and single human T cells, we found no evidence for the monoallelic expression of the IL-2, IL-3, and IL-13 genes. The gene for IL-4 showed an imbalance in expression from each allele, indicating differential expression of IL-4 alleles within or between IL-4-expressing cells
U2 - https://doi.org/10.1002/eji.200323976
DO - https://doi.org/10.1002/eji.200323976
M3 - Article
C2 - 12884288
SN - 0014-2980
VL - 33
SP - 2142
EP - 2148
JO - European journal of immunology
JF - European journal of immunology
IS - 8
ER -