TY - JOUR
T1 - Analysis of attenuation coefficient estimation in Fourier-domain OCT of semi-infinite media
AU - Ghafaryasl, Babak
AU - Vermeer, Koenraad A.
AU - Kalkman, Jeroen
AU - Callewaert, Tom
AU - de Boer, Johannes F.
AU - Van Vliet, Lucas J.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - The attenuation coefficient (AC) is an optical property of tissue that can be estimated from optical coherence tomography (OCT) data. In this paper, we aim to estimate the AC accurately by compensating for the shape of the focused beam. For this, we propose a method to estimate the axial PSF model parameters and AC by fitting a model for an OCT signal in a homogenous sample to the recorded OCT signal. In addition, we employ numerical analysis to obtain the theoretical optimal precision of the estimated parameters for different experimental setups. Finally, the method is applied to OCT B-scans obtained from homogeneous samples. The numerical and experimental results show accurate estimations of the AC and the focus location when the focus is located inside the sample.
AB - The attenuation coefficient (AC) is an optical property of tissue that can be estimated from optical coherence tomography (OCT) data. In this paper, we aim to estimate the AC accurately by compensating for the shape of the focused beam. For this, we propose a method to estimate the axial PSF model parameters and AC by fitting a model for an OCT signal in a homogenous sample to the recorded OCT signal. In addition, we employ numerical analysis to obtain the theoretical optimal precision of the estimated parameters for different experimental setups. Finally, the method is applied to OCT B-scans obtained from homogeneous samples. The numerical and experimental results show accurate estimations of the AC and the focus location when the focus is located inside the sample.
UR - https://www.mendeley.com/catalogue/f21b9e83-b236-303b-84bb-af0956b97540/
U2 - https://doi.org/10.1364/boe.403283
DO - https://doi.org/10.1364/boe.403283
M3 - Article
SN - 2156-7085
VL - 11
SP - 6093
EP - 6107
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 11
ER -