TY - JOUR
T1 - Analysis of Behavioral and Emotional Problems in Children Highlights the Role of Genotype × Environment Interaction
AU - Molenaar, Dylan
AU - Middeldorp, Christel
AU - van Beijsterveldt, Toos
AU - Boomsma, Dorret I.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - This study tested for Genotype × Environment (G × E) interaction on behavioral and emotional problems in children using new methods that do not require identification of candidate genes or environments, can distinguish between interaction with shared and unique environment, and are insensitive to scale effects. Parental ratings of problem behavior from 14,755 twin pairs (5.3 years, SD = 0.22) indicated G × E interaction on emotional liability, social isolation, aggression, attention problems, dependency, anxiety, and physical coordination. Environmental influences increased in children who were genetically more predisposed to problem behavior, with ~20% of the variance due to G × E interaction (8% for anxiety to 37% for attention problems). Ignoring G × E interaction does not greatly bias heritability estimates, but it does offer a comprehensive model of the etiology for childhood problems.
AB - This study tested for Genotype × Environment (G × E) interaction on behavioral and emotional problems in children using new methods that do not require identification of candidate genes or environments, can distinguish between interaction with shared and unique environment, and are insensitive to scale effects. Parental ratings of problem behavior from 14,755 twin pairs (5.3 years, SD = 0.22) indicated G × E interaction on emotional liability, social isolation, aggression, attention problems, dependency, anxiety, and physical coordination. Environmental influences increased in children who were genetically more predisposed to problem behavior, with ~20% of the variance due to G × E interaction (8% for anxiety to 37% for attention problems). Ignoring G × E interaction does not greatly bias heritability estimates, but it does offer a comprehensive model of the etiology for childhood problems.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84945275194&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/26509842
U2 - https://doi.org/10.1111/cdev.12451
DO - https://doi.org/10.1111/cdev.12451
M3 - Article
C2 - 26509842
SN - 0009-3920
VL - 86
SP - 1999
EP - 2016
JO - Child development
JF - Child development
IS - 6
ER -