TY - JOUR
T1 - Analysis of Neuroretinal Rim by Age, Race, and Sex Using High-Density 3-Dimensional Spectral-Domain Optical Coherence Tomography
AU - Antar, Hussein
AU - Tsikata, Edem
AU - Ratanawongphaibul, Kitiya
AU - Zhang, Jing
AU - Shieh, Eric
AU - Lee, Ramon
AU - Freeman, Madeline
AU - Papadogeorgou, Georgia
AU - Simavli, Huseyin
AU - Que, Christian
AU - Verticchio Vercellin, Alice C.
AU - Khoueir, Ziad
AU - De Boer, Johannes F.
AU - Chen, Teresa C.
AU - Simavli, Huseyn
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Précis:Neuroretinal rim minimum distance band (MDB) thickness is significantly lower in older subjects and African Americans compared with whites. It is similar in both sexes.Purpose:To evaluate the relationship between age, race, and sex with the neuroretinal rim using high-density spectral-domain optical coherence tomography optic nerve volume scans of normal eyes.Methods:A total of 256 normal subjects underwent Spectralis spectral-domain optical coherence tomography optic nerve head volume scans. One eye was randomly selected and analyzed for each subject. Using custom-designed software, the neuroretinal rim MDB thickness was calculated from volume scans, and global and quadrant neuroretinal rim thickness values were determined. The MDB is a 3-dimensional neuroretinal rim band comprised of the shortest distance between the internal limiting membrane and the termination of the retinal pigment epithelium/Bruch's membrane complex. Multiple linear regression analysis was performed to determine the associations of age, race, and sex with neuroretinal rim MDB measurements.Results:The population was 57% female and 69% white with a mean age of 58.415.3 years. The mean MDB thickness in the normal population was 278.447.5 m. For this normal population, MDB thickness decreased by 0.84 m annually (P
AB - Précis:Neuroretinal rim minimum distance band (MDB) thickness is significantly lower in older subjects and African Americans compared with whites. It is similar in both sexes.Purpose:To evaluate the relationship between age, race, and sex with the neuroretinal rim using high-density spectral-domain optical coherence tomography optic nerve volume scans of normal eyes.Methods:A total of 256 normal subjects underwent Spectralis spectral-domain optical coherence tomography optic nerve head volume scans. One eye was randomly selected and analyzed for each subject. Using custom-designed software, the neuroretinal rim MDB thickness was calculated from volume scans, and global and quadrant neuroretinal rim thickness values were determined. The MDB is a 3-dimensional neuroretinal rim band comprised of the shortest distance between the internal limiting membrane and the termination of the retinal pigment epithelium/Bruch's membrane complex. Multiple linear regression analysis was performed to determine the associations of age, race, and sex with neuroretinal rim MDB measurements.Results:The population was 57% female and 69% white with a mean age of 58.415.3 years. The mean MDB thickness in the normal population was 278.447.5 m. For this normal population, MDB thickness decreased by 0.84 m annually (P
KW - neuroretinal rim
KW - optic nerve
KW - optical coherence tomography
UR - http://www.mendeley.com/catalogue/analysis-neuroretinal-rim-age-race-sex-using-highdensity-3dimensional-spectraldomain-optical-coheren
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85073743505&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31599775
U2 - https://doi.org/10.1097/IJG.0000000000001381
DO - https://doi.org/10.1097/IJG.0000000000001381
M3 - Article
C2 - 31599775
SN - 1057-0829
VL - 28
SP - 979
EP - 988
JO - Journal of Glaucoma
JF - Journal of Glaucoma
IS - 11
ER -