TY - JOUR
T1 - Analysis of Volatile Organic Compounds in Exhaled Breath Following a COMEX-30 Treatment Table
AU - de Jong, Feiko J. M.
AU - Wingelaar, Thijs T.
AU - Brinkman, Paul
AU - van Ooij, Pieter-Jan A. M.
AU - Maitland-van der Zee, Anke H.
AU - Hollmann, Markus W.
AU - van Hulst, Rob A.
N1 - Publisher Copyright: © 2023 by the authors.
PY - 2023/3/1
Y1 - 2023/3/1
N2 - The COMEX-30 hyperbaric treatment table is used to manage decompression sickness in divers but may result in pulmonary oxygen toxicity (POT). Volatile organic compounds (VOCs) in exhaled breath are early markers of hyperoxic stress that may be linked to POT. The present study assessed whether VOCs following COMEX-30 treatment are early markers of hyperoxic stress and/or POT in ten healthy, nonsmoking volunteers. Because more oxygen is inhaled during COMEX-30 treatment than with other treatment tables, this study hypothesized that VOCs exhaled following COMEX-30 treatment are indicators of POT. Breath samples were collected before and 0.5, 2, and 4 h after COMEX-30 treatment. All subjects were followed-up for signs of POT or other symptoms. Nine compounds were identified, with four (nonanal, decanal, ethyl acetate, and tridecane) increasing 33–500% in intensity from before to after COMEX-30 treatment. Seven subjects reported pulmonary symptoms, five reported out-of-proportion tiredness and transient ear fullness, and four had signs of mild dehydration. All VOCs identified following COMEX-30 treatment have been associated with inflammatory responses or pulmonary diseases, such as asthma or lung cancer. Because most subjects reported transient pulmonary symptoms reflecting early-stage POT, the identified VOCs are likely markers of POT, not just hyperbaric hyperoxic exposure.
AB - The COMEX-30 hyperbaric treatment table is used to manage decompression sickness in divers but may result in pulmonary oxygen toxicity (POT). Volatile organic compounds (VOCs) in exhaled breath are early markers of hyperoxic stress that may be linked to POT. The present study assessed whether VOCs following COMEX-30 treatment are early markers of hyperoxic stress and/or POT in ten healthy, nonsmoking volunteers. Because more oxygen is inhaled during COMEX-30 treatment than with other treatment tables, this study hypothesized that VOCs exhaled following COMEX-30 treatment are indicators of POT. Breath samples were collected before and 0.5, 2, and 4 h after COMEX-30 treatment. All subjects were followed-up for signs of POT or other symptoms. Nine compounds were identified, with four (nonanal, decanal, ethyl acetate, and tridecane) increasing 33–500% in intensity from before to after COMEX-30 treatment. Seven subjects reported pulmonary symptoms, five reported out-of-proportion tiredness and transient ear fullness, and four had signs of mild dehydration. All VOCs identified following COMEX-30 treatment have been associated with inflammatory responses or pulmonary diseases, such as asthma or lung cancer. Because most subjects reported transient pulmonary symptoms reflecting early-stage POT, the identified VOCs are likely markers of POT, not just hyperbaric hyperoxic exposure.
KW - COMEX-30
KW - GC-MS
KW - diving and hyperbaric medicine
KW - exhaled breath markers
KW - hyperbaric oxygen therapy
KW - hyperoxia
KW - pulmonary oxygen toxicity
KW - volatile organic compounds
UR - http://www.scopus.com/inward/record.url?scp=85151504629&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/metabo13030316
DO - https://doi.org/10.3390/metabo13030316
M3 - Article
C2 - 36984755
SN - 2218-1989
VL - 13
JO - Metabolites
JF - Metabolites
IS - 3
M1 - 316
ER -