TY - JOUR
T1 - Anemia in children following renal transplantation-results from the ESPN/ERA-EDTA Registry
AU - Krischock, Leah A.
AU - van Stralen, Karlijn J.
AU - Verrina, Enrico
AU - Tizard, E. Jane
AU - Bonthuis, Marjolein
AU - Reusz, György
AU - Hussain, Farida K.
AU - Jankauskiene, Augustina
AU - Novljan, Gregor
AU - Spasojević-Dimitrijeva, Brankica
AU - Podracka, Ludmila
AU - Zaller, Vera
AU - Jager, Kitty J.
AU - Schaefer, Franz
AU - AUTHOR GROUP
AU - Shtiza, D.
AU - Kramar, R.
AU - Oberbauer, R.
AU - Baiko, S.
AU - Sukalo, A.
AU - van Hoeck, K.
AU - Collart, F.
AU - Grottes, J. M. des
AU - Pokrajac, D.
AU - Roussinov, D.
AU - Batinić, D.
AU - Lemac, M.
AU - Slavicek, J.
AU - Seeman, T.
AU - Vondrak, K.
AU - Heaf, J. G.
AU - Toots, U.
AU - Finne, P.
AU - Grönhagen-Riska, C.
AU - Couchoud, C.
AU - Lasalle, M.
AU - Sahpazova, E.
AU - Abazi, N.
AU - Bojkovska, N. Ristoka
AU - von Gersdorff, G.
AU - Scholz, C.
AU - Tönshoff, B.
AU - Krupka, K.
AU - Höcker, B.
AU - Pape, L.
AU - Afentakis, N.
AU - Kapogiannis, A.
AU - Printza, N.
AU - Reusz, G.
AU - Berecki, Cs
AU - Szabó, A.
PY - 2016
Y1 - 2016
N2 - Our aim was to determine the prevalence of sub-target hemoglobin (Hb) levels in children with a renal allograft and to identify potential determinants associated with these Hb levels. Data from 3669 children with a functioning renal allograft, aged <18 years between 1 January 2000 and 31 December 2012, from 20 European countries were retrieved from the ESPN/ERA-EDTA Registry, providing 16,170 Hb measurements. According to the NKF/KDOQI classification and the UK-NICE guidelines, 49.8 and 7.8% of the patients, respectively, were anemic. Hb levels were strongly associated with graft function, with Hb levels of 12.6 g/dl in children with chronic kidney disease (CKD) stage 1, declining to 10.7 g/dl in children with CKD stage 5 (P < 0.001). Higher Hb levels were associated with the use of tacrolimus compared to ciclosporin (0.14 g/dl; 95% confidence interval 0.02-0.27; P = 0.002). Low Hb levels were associated with an increased risk of graft failure (P = 0.01) or combined graft failure and death (P < 0.01), but not with death alone (not significant). Anemia is present in a significant proportion of European pediatric kidney transplant recipients and is associated with renal allograft dysfunction and type of immunosuppressants used. In our patient cohort, higher Hb levels were associated with better graft and patient survival and less hypertension
AB - Our aim was to determine the prevalence of sub-target hemoglobin (Hb) levels in children with a renal allograft and to identify potential determinants associated with these Hb levels. Data from 3669 children with a functioning renal allograft, aged <18 years between 1 January 2000 and 31 December 2012, from 20 European countries were retrieved from the ESPN/ERA-EDTA Registry, providing 16,170 Hb measurements. According to the NKF/KDOQI classification and the UK-NICE guidelines, 49.8 and 7.8% of the patients, respectively, were anemic. Hb levels were strongly associated with graft function, with Hb levels of 12.6 g/dl in children with chronic kidney disease (CKD) stage 1, declining to 10.7 g/dl in children with CKD stage 5 (P < 0.001). Higher Hb levels were associated with the use of tacrolimus compared to ciclosporin (0.14 g/dl; 95% confidence interval 0.02-0.27; P = 0.002). Low Hb levels were associated with an increased risk of graft failure (P = 0.01) or combined graft failure and death (P < 0.01), but not with death alone (not significant). Anemia is present in a significant proportion of European pediatric kidney transplant recipients and is associated with renal allograft dysfunction and type of immunosuppressants used. In our patient cohort, higher Hb levels were associated with better graft and patient survival and less hypertension
U2 - https://doi.org/10.1007/s00467-015-3201-8
DO - https://doi.org/10.1007/s00467-015-3201-8
M3 - Article
C2 - 26385862
SN - 0931-041X
VL - 31
SP - 325
EP - 333
JO - Pediatric nephrology (Berlin, Germany)
JF - Pediatric nephrology (Berlin, Germany)
IS - 2
ER -