TY - JOUR
T1 - Angiogenesis and Vascular Endothelial Growth Factors in Intraocular Tumors
AU - Missotten, Guy S.
AU - Schlingemann, Reinier O.
AU - Jager, Martine J.
PY - 2010
Y1 - 2010
N2 - The role of angiogenesis in tumors appears obvious: without vessels, tumors cannot grow. However, the long-held belief that all human solid tumors are angiogenesis-dependent has been challenged by the universally disappointing results of anti-angiogenesis therapy in cancer. This may be explained by the fact that cooption of preexisting vasculature as a primary or secondary mechanism of tumor vascularization is more important than previously thought. Nevertheless, anti-angiogenesis therapy may play an important (adjuvant) role in the prevention of metastases of intraocular tumors (uveal melanoma and retinoblastoma). Antivascular endothelial growth factor therapy already plays an important role in the management of irradiation complications in tumor eyes
AB - The role of angiogenesis in tumors appears obvious: without vessels, tumors cannot grow. However, the long-held belief that all human solid tumors are angiogenesis-dependent has been challenged by the universally disappointing results of anti-angiogenesis therapy in cancer. This may be explained by the fact that cooption of preexisting vasculature as a primary or secondary mechanism of tumor vascularization is more important than previously thought. Nevertheless, anti-angiogenesis therapy may play an important (adjuvant) role in the prevention of metastases of intraocular tumors (uveal melanoma and retinoblastoma). Antivascular endothelial growth factor therapy already plays an important role in the management of irradiation complications in tumor eyes
U2 - https://doi.org/10.1159/000320015
DO - https://doi.org/10.1159/000320015
M3 - Article
C2 - 20703038
SN - 0250-3751
VL - 46
SP - 123
EP - 132
JO - Developments in ophthalmology
JF - Developments in ophthalmology
ER -