Abstract
--There is growing evidence that angiotensin II-receptor antagonists may have protective effects for preventing cerebrovascular incidents. --It is unlikely that these effects are due only to a decrease in blood pressure. --One hypothesis is that high concentrations ofangiotensin II result in improved cerebral perfusion ofangiotensin type 2-receptor mediated mechanisms such as local vasodilatation and angiogenesis. --Several clinical and preclinical studies support this hypothesis. --The results of these studies are discussed in this overview. There is still insufficient evidence that a protective effect on the brain occurs
Original language | Dutch |
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Pages (from-to) | 71-75 |
Journal | Nederlands Tijdschrift voor Geneeskunde |
Volume | 152 |
Issue number | 2 |
Publication status | Published - 2008 |