TY - JOUR
T1 - Ano-genital granulomatosis: The counterpart of oro-facial granulomatosis
AU - van de Scheur, M.R.
AU - van der Waal, R.I.F.
AU - van der Waal, I.
AU - Stoof, T.J.
AU - van Deventer, S.J.H.
PY - 2003
Y1 - 2003
N2 - Ano-genital granulomatosis encompasses the previously recognized clinical entities of vulvitis granulomatosa, posthitis granulomatosa, and ano-perineitis granulomatosa. We report three patients with ano-genital granulomatosis. The pathological features of the disease are lymphoedema and the presence of non-caseating giant cell granulomas. These granulomas are histologically indistinguishable from those found in both Crohn's disease and sarcoidosis, therefore, patients with ano-genital granulomatosis with accompanying gastro-intestinal or pulmonary symptoms should be investigated for the presence of Crohn's disease or sarcoidosis, respectively. The value of ano-genital granulomatosis as a unifying clinicopathologic concept is to provide a label for the affliction as well as to stimulate a careful search for possibly underlying systemic disorders, thus also permitting a more specific approach to therapy
AB - Ano-genital granulomatosis encompasses the previously recognized clinical entities of vulvitis granulomatosa, posthitis granulomatosa, and ano-perineitis granulomatosa. We report three patients with ano-genital granulomatosis. The pathological features of the disease are lymphoedema and the presence of non-caseating giant cell granulomas. These granulomas are histologically indistinguishable from those found in both Crohn's disease and sarcoidosis, therefore, patients with ano-genital granulomatosis with accompanying gastro-intestinal or pulmonary symptoms should be investigated for the presence of Crohn's disease or sarcoidosis, respectively. The value of ano-genital granulomatosis as a unifying clinicopathologic concept is to provide a label for the affliction as well as to stimulate a careful search for possibly underlying systemic disorders, thus also permitting a more specific approach to therapy
U2 - https://doi.org/10.1046/j.1468-3083.2003.00573.x
DO - https://doi.org/10.1046/j.1468-3083.2003.00573.x
M3 - Article
C2 - 12705748
SN - 0926-9959
VL - 17
SP - 184
EP - 189
JO - JEADV. Journal of the European Academy of Dermatology and Venereology
JF - JEADV. Journal of the European Academy of Dermatology and Venereology
IS - 2
ER -