Abstract
Objective: To evaluate the role of antenatal administration of corticosteroids for fetal lung maturation on the short-term perinatal outcome of pregnancy complicated by late fetal growth restriction (FGR). Methods: This cohort study was a secondary analysis of a multicenter prospective observational study, the TRUFFLE-2 feasibility study, conducted between 2017 and 2018 in 33 European perinatal centers. The study included women with a singleton pregnancy from 32 + 0 to 36 + 6 weeks of gestation with a fetus considered at risk for FGR, defined as estimated fetal weight (EFW) and/or fetal abdominal circumference < 10th percentile, or umbilicocerebral ratio (UCR) ≥ 95th percentile or a drop of more than 40 percentile points in abdominal circumference measurement from the 20-week scan. For the purposes of the current study, we identified women who received a single course of steroids to improve fetal lung maturation before delivery. Each exposed pregnancy was matched with one that did not receive antenatal corticosteroids (ACS) (control), based on gestational age at delivery and birth weight. The primary adverse outcome was a composite of abnormal condition at birth, major neonatal morbidity or perinatal death. Results: A total of 86 pregnancies that received ACS were matched to 86 controls. The two groups were similar with respect to gestational age (33.1 vs 33.3 weeks), EFW (1673 vs 1634 g) and UCR (0.68 vs 0.62) at inclusion, and gestational age at delivery (35.5 vs 35.9 weeks) and birth weight (1925 vs 1948 g). No significant differences were observed between the exposed and non-exposed groups in the incidence of composite adverse outcome (28% vs 24%; P = 0.73) or any of its elements. Conclusion: The present data do not show a beneficial effect of steroids on short-term outcome of fetuses with late FGR.
Original language | English |
---|---|
Pages (from-to) | 191-197 |
Number of pages | 7 |
Journal | Ultrasound in Obstetrics & Gynecology |
Volume | 61 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Feb 2023 |
Keywords
- antenatal corticosteroids
- fetal growth restriction
- fetal lung maturation
- late preterm
Access to Document
Other files and links
Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
In: Ultrasound in Obstetrics & Gynecology, Vol. 61, No. 2, 01.02.2023, p. 191-197.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Antenatal corticosteroids and perinatal outcome in late fetal growth restriction
T2 - analysis of prospective cohort
AU - Familiari, A.
AU - Napolitano, R.
AU - Visser, G. H. A.
AU - Lees, C.
AU - Wolf, H.
AU - Prefumo, F.
AU - the TRUFFLE-2 feasibility study investigators
AU - Arabin, B.
AU - Berger, A.
AU - Bergman, E.
AU - Bhide, A.
AU - Bilardo, C. M.
AU - Breeze, A. C.
AU - Brodszki, J.
AU - Calda, P.
AU - Cesari, E.
AU - Cetin, I.
AU - Derks, J. B.
AU - Ebbing, C.
AU - Ferrazzi, E.
AU - Frusca, T.
AU - Ganzevoort, W.
AU - Gordijn, S. J.
AU - Gyselaers, W.
AU - Hecher, K.
AU - Klaritsch, P.
AU - Krofta, L.
AU - Lindgren, P.
AU - Lobmaier, S. M.
AU - Marlow, N.
AU - Maruotti, G. M.
AU - Mecacci, F.
AU - Myklestad, K.
AU - Mylrea-Foley, B.
AU - Raio, L.
AU - Richter, J.
AU - Sande, R. K.
AU - Stampalija, T.
AU - Thornton, J.
AU - Valensise, H.
AU - Wee, L.
N1 - Funding Information: C.L. is supported by the NIHR Biomedical Research Centre (BRC) based at Imperial College Healthcare NHS Trust and Imperial College London, London, UK. B. Arabin, Department of Obstetrics Charite, Humboldt University Berlin and Clara Angela Foundation, Berlin, Germany A. Berger, Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Austria E. Bergman, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden A. Bhide, Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK; Molecular & Clinical Sciences Research Institute, St George's University of London, London, UK C. M. Bilardo, Department of Obstetrics and Gynecology, Amsterdam University Medical Centers, University of Amsterdam, Location VUMC, Amsterdam, The Netherlands A. C. Breeze, Fetal Medicine Unit, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK J. Brodszki, Department of Pediatric Surgery and Neonatology, Lund University, Skane University Hospital, Lund, Sweden P. Calda, Department of Obstetrics and Gynecology, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic E. Cesari, Department of Obstetrics and Gynecology, Vittore Buzzi Children's Hospital, University of Milan, Milan, Italy I. Cetin, Department of Obstetrics and Gynecology, Vittore Buzzi Children's Hospital, University of Milan, Milan, Italy J. B. Derks, Department of Perinatal Medicine, University of Utrecht, Utrecht, The Netherlands C. Ebbing, Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway E. Ferrazzi, Department of Obstetrics and Gynecology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy T. Frusca, Department of Obstetrics and Gynecology, University of Parma, Parma, Italy W. Ganzevoort, Department of Obstetrics and Gynecology, Amsterdam University Medical Centers, location AMC, Amsterdam, The Netherlands S. J. Gordijn, Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands W. Gyselaers, Faculty of Medicine and Life Sciences, Hasselt University, Agoralaan, Diepenbeek, Belgium; Department of Obstetrics & Gynecology, Ziekenhuis Oost-Limburg, Genk and Department Physiology, Hasselt University, Diepenbeek, Belgium K. Hecher, Department of Obstetrics and Fetal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany P. Klaritsch, Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria L. Krofta, Institute for the Care of Mother and Child, Prague, Czech Republic; Third Medical Faculty, Charles University, Prague, Czech Republic P. Lindgren, Center for Fetal Medicine, Karolinska University Hospital, Stockholm, Sweden S. M. Lobmaier, Department of Obstetrics and Gynecology, Klinikum Rechts Der Isar, Technical University of Munich, Munich, Germany N. Marlow, UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK G. M. Maruotti, Department of Neurosciences, Reproductive and Dentistry Sciences, University of Naples‘Federico II’, Naples, Italy F. Mecacci, Department of Health Sciences, University of Florence, Obstetrics and Gynecology, Careggi University Hospital, Florence, Italy K. Myklestad, St Olav's Hospital, Trondheim, Norway B. Mylrea-Foley, Imperial College London, London, UK L. Raio, Department of Obstetrics & Gynecology, University Hospital of Bern, Bern, Switzerland J. Richter, Department of Gynecology and Obstetrics, UZ Leuven and Department of Regeneration and Development, KU Leuven, Leuven, Belgium R. K. Sande, Department of Obstetrics and Gynecology, Stavanger University Hospital, Stavanger and Depart ment of Clinical Science, University of Bergen, Bergen, Norway T. Stampalija, Unit of Fetal Medicine and Prenatal Diagnosis, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy J. Thornton, School of Clinical Sciences, University of Nottingham, Division of Obstetrics and Gynaecology, Maternity Department, City Hospital, Nottingham, UK H. Valensise, Department of Surgery, Division of Obstetrics and Gynecology, Tor Vergata, University, Policlinico Casilino Hospital, Rome, Italy L. Wee, The Princess Alexandra Hospital NHS Trust, Harlow, UK Publisher Copyright: © 2023 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
PY - 2023/2/1
Y1 - 2023/2/1
N2 - Objective: To evaluate the role of antenatal administration of corticosteroids for fetal lung maturation on the short-term perinatal outcome of pregnancy complicated by late fetal growth restriction (FGR). Methods: This cohort study was a secondary analysis of a multicenter prospective observational study, the TRUFFLE-2 feasibility study, conducted between 2017 and 2018 in 33 European perinatal centers. The study included women with a singleton pregnancy from 32 + 0 to 36 + 6 weeks of gestation with a fetus considered at risk for FGR, defined as estimated fetal weight (EFW) and/or fetal abdominal circumference < 10th percentile, or umbilicocerebral ratio (UCR) ≥ 95th percentile or a drop of more than 40 percentile points in abdominal circumference measurement from the 20-week scan. For the purposes of the current study, we identified women who received a single course of steroids to improve fetal lung maturation before delivery. Each exposed pregnancy was matched with one that did not receive antenatal corticosteroids (ACS) (control), based on gestational age at delivery and birth weight. The primary adverse outcome was a composite of abnormal condition at birth, major neonatal morbidity or perinatal death. Results: A total of 86 pregnancies that received ACS were matched to 86 controls. The two groups were similar with respect to gestational age (33.1 vs 33.3 weeks), EFW (1673 vs 1634 g) and UCR (0.68 vs 0.62) at inclusion, and gestational age at delivery (35.5 vs 35.9 weeks) and birth weight (1925 vs 1948 g). No significant differences were observed between the exposed and non-exposed groups in the incidence of composite adverse outcome (28% vs 24%; P = 0.73) or any of its elements. Conclusion: The present data do not show a beneficial effect of steroids on short-term outcome of fetuses with late FGR.
AB - Objective: To evaluate the role of antenatal administration of corticosteroids for fetal lung maturation on the short-term perinatal outcome of pregnancy complicated by late fetal growth restriction (FGR). Methods: This cohort study was a secondary analysis of a multicenter prospective observational study, the TRUFFLE-2 feasibility study, conducted between 2017 and 2018 in 33 European perinatal centers. The study included women with a singleton pregnancy from 32 + 0 to 36 + 6 weeks of gestation with a fetus considered at risk for FGR, defined as estimated fetal weight (EFW) and/or fetal abdominal circumference < 10th percentile, or umbilicocerebral ratio (UCR) ≥ 95th percentile or a drop of more than 40 percentile points in abdominal circumference measurement from the 20-week scan. For the purposes of the current study, we identified women who received a single course of steroids to improve fetal lung maturation before delivery. Each exposed pregnancy was matched with one that did not receive antenatal corticosteroids (ACS) (control), based on gestational age at delivery and birth weight. The primary adverse outcome was a composite of abnormal condition at birth, major neonatal morbidity or perinatal death. Results: A total of 86 pregnancies that received ACS were matched to 86 controls. The two groups were similar with respect to gestational age (33.1 vs 33.3 weeks), EFW (1673 vs 1634 g) and UCR (0.68 vs 0.62) at inclusion, and gestational age at delivery (35.5 vs 35.9 weeks) and birth weight (1925 vs 1948 g). No significant differences were observed between the exposed and non-exposed groups in the incidence of composite adverse outcome (28% vs 24%; P = 0.73) or any of its elements. Conclusion: The present data do not show a beneficial effect of steroids on short-term outcome of fetuses with late FGR.
KW - antenatal corticosteroids
KW - fetal growth restriction
KW - fetal lung maturation
KW - late preterm
UR - http://www.scopus.com/inward/record.url?scp=85147234874&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/uog.26127
DO - https://doi.org/10.1002/uog.26127
M3 - Article
C2 - 36412975
SN - 0960-7692
VL - 61
SP - 191
EP - 197
JO - Ultrasound in Obstetrics & Gynecology
JF - Ultrasound in Obstetrics & Gynecology
IS - 2
ER -