TY - JOUR
T1 - Anti-mullerian hormone is a sensitive serum marker for gonadal function in women treated for Hodgkin's lymphoma during childhood
AU - van Beek, Robert D.
AU - van den Heuvel-Eibrink, Marry M.
AU - Laven, Joop S. E.
AU - de Jong, Frank H.
AU - Themmen, Axel P. N.
AU - Hakvoort-Cammel, Friederike G.
AU - van den Bos, Cor
AU - van den Berg, Henk
AU - Pieters, Rob
AU - Keizer-Schrama, Sabine M. P. F. de Muinck
PY - 2007
Y1 - 2007
N2 - Purpose: The aim of this study was to evaluate the long-term effects of combination chemotherapy treatment for girls with Hodgkin's lymphoma ( HL) on gonadal function using anti-Mullerian hormone ( AMH) and inhibin B as ovarian reserve parameters. Patients and Methods: LH, FSH, inhibin B, and AMH were measured in 32 women treated from 1974 to 1998 for pediatric HL with chemotherapy, with the intention to avoid radiotherapy. All patients [ median age 25.0 yr ( range 19.2-40.4 yr)] were in complete remission with a median follow-up time of 14.0 yr ( range 5.7-24.5 yr) after therapy. All patients were treated with combination chemotherapy doxorubicin, bleomycin, vinblastine and dacarbazine ( ABVD) or EBVD with or without mechlorethamine, vincristine, procarbazine, and prednisone ( MOPP). Because of incomplete remission or relapse, involved field radiotherapy was needed in seven of 32 women. Results were compared with a healthy control group. Results: Patients treated with six or more cycles of MOPP combination chemotherapy had significantly higher levels of FSH and lower serum levels of inhibin B and AMH, compared with healthy women [ FSH, 17.0 vs. 6.0 U/liter ( P <0.05); inhibin B, 23.0 vs. 112.5 ng/ liter ( P <0.01); AMH, 0.39 vs. 2.10 mu g/ liter ( P <0.01)]. AMH was also significantly lower, compared with women treated without MOPP ( median 0.39 vs. 1.40 mu g/ liter; P = 0.01). Conclusions: Women treated during childhood for HL with MOPP seem to have a distinctly lower ovarian reserve as measured by lower AMH values at early adulthood, compared with healthy women. Moreover, AMH seems to be the only predictor that is sufficiently sensitive to detect this decrease in ovarian reserve
AB - Purpose: The aim of this study was to evaluate the long-term effects of combination chemotherapy treatment for girls with Hodgkin's lymphoma ( HL) on gonadal function using anti-Mullerian hormone ( AMH) and inhibin B as ovarian reserve parameters. Patients and Methods: LH, FSH, inhibin B, and AMH were measured in 32 women treated from 1974 to 1998 for pediatric HL with chemotherapy, with the intention to avoid radiotherapy. All patients [ median age 25.0 yr ( range 19.2-40.4 yr)] were in complete remission with a median follow-up time of 14.0 yr ( range 5.7-24.5 yr) after therapy. All patients were treated with combination chemotherapy doxorubicin, bleomycin, vinblastine and dacarbazine ( ABVD) or EBVD with or without mechlorethamine, vincristine, procarbazine, and prednisone ( MOPP). Because of incomplete remission or relapse, involved field radiotherapy was needed in seven of 32 women. Results were compared with a healthy control group. Results: Patients treated with six or more cycles of MOPP combination chemotherapy had significantly higher levels of FSH and lower serum levels of inhibin B and AMH, compared with healthy women [ FSH, 17.0 vs. 6.0 U/liter ( P <0.05); inhibin B, 23.0 vs. 112.5 ng/ liter ( P <0.01); AMH, 0.39 vs. 2.10 mu g/ liter ( P <0.01)]. AMH was also significantly lower, compared with women treated without MOPP ( median 0.39 vs. 1.40 mu g/ liter; P = 0.01). Conclusions: Women treated during childhood for HL with MOPP seem to have a distinctly lower ovarian reserve as measured by lower AMH values at early adulthood, compared with healthy women. Moreover, AMH seems to be the only predictor that is sufficiently sensitive to detect this decrease in ovarian reserve
U2 - https://doi.org/10.1210/jc.2006-2374
DO - https://doi.org/10.1210/jc.2006-2374
M3 - Article
C2 - 17726078
SN - 0021-972X
VL - 92
SP - 3869
EP - 3874
JO - Journal of clinical endocrinology and metabolism
JF - Journal of clinical endocrinology and metabolism
IS - 10
ER -