TY - JOUR
T1 - Anticardiolipin antibodies in D+ hemolytic uremic syndrome
AU - te Loo, Maroeska
AU - van der Velden, Thea
AU - Onland, Wes
AU - van den Heuvel, Lambertus
AU - Monnens, Leo
PY - 2002
Y1 - 2002
N2 - The diarrhea-associated form of the hemolytic uremic syndrome (D+ HUS) is characterized by a triad of symptoms, namely thrombocytopenia, hemolytic anemia, and acute renal failure. Histopathological studies of patients with D+ HUS show microthrombi in arterioles and glomeruli of the kidney. Recently, it was suggested that antiphospholipid antibodies might play a pathogenic role in D+ HUS. However, an epiphenomenon could not be excluded. In this study we investigated the relationship between antiphospholipid antibodies and clinical symptoms in 22 patients with the classical form of HUS (D+ HUS). The first sample was obtained on the day of admission. The next samples were taken on day 7 and 14. We measured anticardiolipin (aCL) antibodies (IgM, IgA, and IgG) in the samples using an ELISA. A significant increase in IgM (60%) and IgG (41%) aCL antibodies was seen in patients versus controls. No relationship between aCL antibody levels and severity of renal failure could be demonstrated. These data suggest that antiphospholipid antibodies are increased, but have not been shown to have a role in the pathogenesis of the microangiopathy seen in D+HUS.
AB - The diarrhea-associated form of the hemolytic uremic syndrome (D+ HUS) is characterized by a triad of symptoms, namely thrombocytopenia, hemolytic anemia, and acute renal failure. Histopathological studies of patients with D+ HUS show microthrombi in arterioles and glomeruli of the kidney. Recently, it was suggested that antiphospholipid antibodies might play a pathogenic role in D+ HUS. However, an epiphenomenon could not be excluded. In this study we investigated the relationship between antiphospholipid antibodies and clinical symptoms in 22 patients with the classical form of HUS (D+ HUS). The first sample was obtained on the day of admission. The next samples were taken on day 7 and 14. We measured anticardiolipin (aCL) antibodies (IgM, IgA, and IgG) in the samples using an ELISA. A significant increase in IgM (60%) and IgG (41%) aCL antibodies was seen in patients versus controls. No relationship between aCL antibody levels and severity of renal failure could be demonstrated. These data suggest that antiphospholipid antibodies are increased, but have not been shown to have a role in the pathogenesis of the microangiopathy seen in D+HUS.
KW - Anticardiolipin antibodies
KW - Creatinine
KW - D+ hemolytic uremic syndrome
KW - Severity of renal failure
KW - White blood cell count
UR - http://www.scopus.com/inward/record.url?scp=0036952836&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s00467-002-0965-4
DO - https://doi.org/10.1007/s00467-002-0965-4
M3 - Article
C2 - 12478355
SN - 0931-041X
VL - 17
SP - 1042
EP - 1046
JO - Pediatric Nephrology
JF - Pediatric Nephrology
IS - 12
ER -