TY - JOUR
T1 - Antigen bias in T cell cross-priming
AU - Wolkers, Monika C.
AU - Brouwenstijn, Nathalie
AU - Bakker, Arnold H.
AU - Toebes, Mireille
AU - Schumacher, Ton N. M.
PY - 2004
Y1 - 2004
N2 - Activated CD8(+) T cells detect virally infected cells and tumor cells by recognition of major histocompatibility complex class I-bound peptides derived from degraded, endogenously produced proteins. In contrast, CD8(+) T cell activation often occurs through interaction with specialized antigen-presenting cells displaying peptides acquired from an exogenous cellular source, a process termed cross-priming. Here, we observed a marked inefficiency in exogenous presentation of epitopes derived from signal sequences in mouse models. These data indicate that certain virus- and tumor-associated antigens may not be detected by CD8(+) T cells because of impaired cross-priming. Such differences in the ability to cross-present antigens should form important considerations in vaccine design
AB - Activated CD8(+) T cells detect virally infected cells and tumor cells by recognition of major histocompatibility complex class I-bound peptides derived from degraded, endogenously produced proteins. In contrast, CD8(+) T cell activation often occurs through interaction with specialized antigen-presenting cells displaying peptides acquired from an exogenous cellular source, a process termed cross-priming. Here, we observed a marked inefficiency in exogenous presentation of epitopes derived from signal sequences in mouse models. These data indicate that certain virus- and tumor-associated antigens may not be detected by CD8(+) T cells because of impaired cross-priming. Such differences in the ability to cross-present antigens should form important considerations in vaccine design
U2 - https://doi.org/10.1126/science.1096268
DO - https://doi.org/10.1126/science.1096268
M3 - Article
C2 - 15166378
SN - 0036-8075
VL - 304
SP - 1314
EP - 1317
JO - Science
JF - Science
IS - 5675
ER -