Antigen-specificity measurements are the key to understanding T cell responses

Rashmi Tippalagama, Leila Y. Chihab, Kendall Kearns, Sloan Lewis, Sudhasini Panda, Lisa Willemsen, Julie G. Burel, Cecilia S. Lindestam Arlehamn

Research output: Contribution to journalReview articleAcademicpeer-review

1 Citation (Scopus)

Abstract

Antigen-specific T cells play a central role in the adaptive immune response and come in a wide range of phenotypes. T cell receptors (TCRs) mediate the antigen-specificities found in T cells. Importantly, high-throughput TCR sequencing provides a fingerprint which allows tracking of specific T cells and their clonal expansion in response to particular antigens. As a result, many studies have leveraged TCR sequencing in an attempt to elucidate the role of antigen-specific T cells in various contexts. Here, we discuss the published approaches to studying antigen-specific T cells and their specific TCR repertoire. Further, we discuss how these methods have been applied to study the TCR repertoire in various diseases in order to characterize the antigen-specific T cells involved in the immune control of disease.
Original languageEnglish
Article number1127470
Pages (from-to)1127470
Number of pages1
JournalFrontiers in immunology
Volume14
DOIs
Publication statusPublished - 2023
Externally publishedYes

Keywords

  • T cell
  • TCR
  • adaptive immunity
  • antigen-specificity
  • sequencing

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