Abstract
Antigen-specific T cells play a central role in the adaptive immune response and come in a wide range of phenotypes. T cell receptors (TCRs) mediate the antigen-specificities found in T cells. Importantly, high-throughput TCR sequencing provides a fingerprint which allows tracking of specific T cells and their clonal expansion in response to particular antigens. As a result, many studies have leveraged TCR sequencing in an attempt to elucidate the role of antigen-specific T cells in various contexts. Here, we discuss the published approaches to studying antigen-specific T cells and their specific TCR repertoire. Further, we discuss how these methods have been applied to study the TCR repertoire in various diseases in order to characterize the antigen-specific T cells involved in the immune control of disease.
Original language | English |
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Article number | 1127470 |
Pages (from-to) | 1127470 |
Number of pages | 1 |
Journal | Frontiers in immunology |
Volume | 14 |
DOIs | |
Publication status | Published - 2023 |
Externally published | Yes |
Keywords
- T cell
- TCR
- adaptive immunity
- antigen-specificity
- sequencing