Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags

Oscar Breukels, Toon van der Gronde, Kathleen Simons-Sanders, Mirjam Crul

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Eight Dutch hospital pharmacies took wipe samples of prepared infusion bags containing 5 fluorouracil just before distribution to the wards. The samples were tested with high-performance liquid chromatography and triple quadrupole mass spectroscopy. The limit of detection was 10 ng per swipe. None of the 146 samples had a detectable amount of 5-fluorouracil. The outside of infusion bags containing antineoplastic drugs prepared in these eight Dutch hospital pharmacies were not contaminated and, therefore, were not a risk factor with regard to exposure of hospital workers to antineoplastic drugs.
Original languageEnglish
Pages (from-to)345-349
JournalInternational journal of pharmaceutical compounding
Issue number4
Publication statusPublished - 2018

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