TY - JOUR
T1 - Antithrombotic Strategy in Secondary Prevention for High-Risk Patients with Previous Acute Coronary Syndrome
T2 - Overlap between the PEGASUS Eligibility and the COMPASS Eligibility in a Large Multicenter Registry
AU - Millesimo, Michele
AU - Elia, Edoardo
AU - Marengo, Giorgio
AU - de Filippo, Ovidio
AU - Raposeiras-Roubin, Sergio
AU - Wańha, Wojciech
AU - Abu-Assi, Emad
AU - Kinnaird, Tim
AU - Ariza-Solé, Albert
AU - Liebetrau, Christoph
AU - Manzano-Fernández, Sergio
AU - Iannaccone, Mario
AU - Henriques, Jose Paulo Simao
AU - Templin, Christian
AU - Wilton, Stephen B.
AU - Velicki, Lazar
AU - Xanthopoulou, Ioanna
AU - Correia, Luis
AU - Cerrato, Enrico
AU - Rognoni, Andrea
AU - Nuñez-Gil, Iván
AU - Song, Xiantao
AU - Kawaji, Tetsuma
AU - Quadri, Giorgio
AU - Huczek, Zenon
AU - Paz, Rafael Cobas
AU - Juanatey, José Ramón González
AU - Nie, Shao-Ping
AU - Kawashiri, Masa-aki
AU - Dominguez-Rodriguez, Alberto
AU - Conrotto, Federico
AU - D’Ascenzo, Fabrizio
AU - de Ferrari, Gaetano Maria
N1 - Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2023/1
Y1 - 2023/1
N2 - Background: Patients with previous acute coronary syndrome (ACS) are at high risk of recurrent adverse cardiovascular events. Recently, prolonged dual antiplatelet therapy (DAPT) and oral anticoagulation therapy (OAT) have been shown to reduce recurrent ischemic events to the expense of an increase in bleeding events. The number of patients potentially eligible for these therapies in real life remains to be determined. Methods: Among ACS patients from five registries and one randomized controlled trial, we assessed the proportion of patients eligible for the PEGASUS strategy only and the proportion of patients eligible for the COMPASS strategy only, and set out the proportion of patients with an overlap between the strategies. Findings: Among the 10,048 evaluable patients, we found that 5373 (53.4%) were eligible for the PEGASUS strategy and 3841 (38.2%) were eligible for the COMPASS strategy, with a group of 3444 (34.4%) overlapping between the two strategies. The number of patients eligible for the PEGASUS strategy only was 1929 (19.2%) and the number eligible for the COMPASS strategy only was 397 (4.0%); 4278 (42.6%) were eligible for neither a PEGASUS strategy nor a COMPASS strategy. Interpretation: In a large cohort of ACS patients, one in three patients was eligible for either a prolonged DAPT with ticagrelor 60 mg and low-dose aspirin or a dual pathway inhibition approach with rivaroxaban 2.5 mg and low-dose aspirin.
AB - Background: Patients with previous acute coronary syndrome (ACS) are at high risk of recurrent adverse cardiovascular events. Recently, prolonged dual antiplatelet therapy (DAPT) and oral anticoagulation therapy (OAT) have been shown to reduce recurrent ischemic events to the expense of an increase in bleeding events. The number of patients potentially eligible for these therapies in real life remains to be determined. Methods: Among ACS patients from five registries and one randomized controlled trial, we assessed the proportion of patients eligible for the PEGASUS strategy only and the proportion of patients eligible for the COMPASS strategy only, and set out the proportion of patients with an overlap between the strategies. Findings: Among the 10,048 evaluable patients, we found that 5373 (53.4%) were eligible for the PEGASUS strategy and 3841 (38.2%) were eligible for the COMPASS strategy, with a group of 3444 (34.4%) overlapping between the two strategies. The number of patients eligible for the PEGASUS strategy only was 1929 (19.2%) and the number eligible for the COMPASS strategy only was 397 (4.0%); 4278 (42.6%) were eligible for neither a PEGASUS strategy nor a COMPASS strategy. Interpretation: In a large cohort of ACS patients, one in three patients was eligible for either a prolonged DAPT with ticagrelor 60 mg and low-dose aspirin or a dual pathway inhibition approach with rivaroxaban 2.5 mg and low-dose aspirin.
UR - http://www.scopus.com/inward/record.url?scp=85140973014&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s40256-022-00554-5
DO - https://doi.org/10.1007/s40256-022-00554-5
M3 - Article
C2 - 36316613
SN - 1175-3277
VL - 23
SP - 77
EP - 87
JO - American journal of cardiovascular drugs
JF - American journal of cardiovascular drugs
IS - 1
ER -