TY - JOUR
T1 - Antiviral Immune Responses by Human Langerhans Cells and Dendritic Cells in HIV-1 Infection
AU - van den Berg, Linda M.
AU - Geijtenbeek, Teunis B. H.
PY - 2013
Y1 - 2013
N2 - The main route of human immunodeficiency virus-1 (HIV-1) infection is via unprotected sexual intercourse, and therefore, vaginal tissues and male foreskin are viral entry sites. Langerhans cells (LCs) and dendritic cells (DCs) are amongst the first immune cells encountering HIV-1 since these cells line these mucosal tissues. Both LCs and DCs are equipped with specific pattern recognition receptors that not only sense pathogens, but induce specific immune responses against these pathogens. LCs express the C-type lectin receptor langerin, which provides protection against HIV-1 infection. In contrast, DCs express the C-type lectin receptor DC-SIGN, which facilitates capture as well as infection of DCs and subsequent transmission to CD4(+) T cells. This chapter gives an update on immune responses elicited against viruses and sheds a light on different immune mechanisms that are hijacked by HIV-1 to infect the host. HIV-1 infection ultimately leads to the world-wide pandemic acquired immunodeficiency syndrome (AIDS)
AB - The main route of human immunodeficiency virus-1 (HIV-1) infection is via unprotected sexual intercourse, and therefore, vaginal tissues and male foreskin are viral entry sites. Langerhans cells (LCs) and dendritic cells (DCs) are amongst the first immune cells encountering HIV-1 since these cells line these mucosal tissues. Both LCs and DCs are equipped with specific pattern recognition receptors that not only sense pathogens, but induce specific immune responses against these pathogens. LCs express the C-type lectin receptor langerin, which provides protection against HIV-1 infection. In contrast, DCs express the C-type lectin receptor DC-SIGN, which facilitates capture as well as infection of DCs and subsequent transmission to CD4(+) T cells. This chapter gives an update on immune responses elicited against viruses and sheds a light on different immune mechanisms that are hijacked by HIV-1 to infect the host. HIV-1 infection ultimately leads to the world-wide pandemic acquired immunodeficiency syndrome (AIDS)
U2 - https://doi.org/10.1007/978-1-4614-4433-6_2
DO - https://doi.org/10.1007/978-1-4614-4433-6_2
M3 - Article
C2 - 22975871
SN - 0065-2598
VL - 762
SP - 45
EP - 70
JO - Advances in experimental medicine and biology
JF - Advances in experimental medicine and biology
ER -