TY - JOUR
T1 - Aortic stiffness aging is influenced by past profound immunodeficiency in HIV-infected individuals
T2 - Results from the EVAS-HIV (EValuation of Aortic Stiffness in HIV-infected individuals)
AU - Maia-Leite, Luísa H.
AU - Catez, Emmanuel
AU - Boyd, Anders
AU - Haddour, Nabila
AU - Curjol, Angelique
AU - Lang, Sylvie
AU - Nuernberg, Mabel
AU - Duvivier, Claudine
AU - Desvarieux, Moise
AU - Kirstetter, Miriam
AU - Girard, Pierre-Marie
AU - Cohen, Ariel
AU - Boccara, Franck
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Objective: We compared aortic stiffness between HIV-infected and HIV-uninfected individuals and examined the determinants of vascular aging during HIV infection. Methods: Aortic stiffness using carotid-femoral pulse wave velocity (cf-PWV) was evaluated cross-sectionally between HIV-infected individuals and uninfected controls frequency-matched for age and sex, and longitudinally in a subgroup of HIV-infected individuals. Determinants of elevated cf-PWV levels were assessed using logistic regression. Changes in cf-PWV levels during follow-up (mixed-effect linear regression) and risk factors for achieving cf-PWV below (Group 1) or above the median (Group 2) at last follow-up visit were evaluated only in HIV-infected individuals. Results: A total of 133 HIV-infected and 135 HIV-uninfected individuals (mean age: 47.7±8.9 years, 91% men) were enrolled. Median cf-PWV at baseline was similar between HIV-infected individuals and controls [7.5m/s (interquartile range=6.7-8.4) vs. 7.5m/s (interquartile range=6.6-8.4), respectively; P=0.64]. In multivariable analysis, only mean arterial pressure showed significant association with elevated cf-PWV in the overall population (P=0.036). In HIV-infected individuals, elevated cf-PWV was associated with current smoking (P=0.042), and nadir CD4 + T-cell count less than 200 cells/μl (P=0.048). Ninety-one HIV-infected individuals were followed for a mean 7.6±2.0 years. cf-PWV progression was associated with age (P=0.018), mean arterial pressure (P=0.020), and nadir CD4 + T-cell count (P=0.005). Patients from Group 2 had higher baseline waist circumference, pulse pressure, and nadir CD4 + T-cell count less than 200 cells/μl. Conclusion: We observed no difference in aortic stiffness between HIV-infected and controls. Moreover, aortic stiffness aging was independently associated with past severe immunodeficiency, along with other traditional risk factors. Our results call for early antiretroviral initiation.
AB - Objective: We compared aortic stiffness between HIV-infected and HIV-uninfected individuals and examined the determinants of vascular aging during HIV infection. Methods: Aortic stiffness using carotid-femoral pulse wave velocity (cf-PWV) was evaluated cross-sectionally between HIV-infected individuals and uninfected controls frequency-matched for age and sex, and longitudinally in a subgroup of HIV-infected individuals. Determinants of elevated cf-PWV levels were assessed using logistic regression. Changes in cf-PWV levels during follow-up (mixed-effect linear regression) and risk factors for achieving cf-PWV below (Group 1) or above the median (Group 2) at last follow-up visit were evaluated only in HIV-infected individuals. Results: A total of 133 HIV-infected and 135 HIV-uninfected individuals (mean age: 47.7±8.9 years, 91% men) were enrolled. Median cf-PWV at baseline was similar between HIV-infected individuals and controls [7.5m/s (interquartile range=6.7-8.4) vs. 7.5m/s (interquartile range=6.6-8.4), respectively; P=0.64]. In multivariable analysis, only mean arterial pressure showed significant association with elevated cf-PWV in the overall population (P=0.036). In HIV-infected individuals, elevated cf-PWV was associated with current smoking (P=0.042), and nadir CD4 + T-cell count less than 200 cells/μl (P=0.048). Ninety-one HIV-infected individuals were followed for a mean 7.6±2.0 years. cf-PWV progression was associated with age (P=0.018), mean arterial pressure (P=0.020), and nadir CD4 + T-cell count (P=0.005). Patients from Group 2 had higher baseline waist circumference, pulse pressure, and nadir CD4 + T-cell count less than 200 cells/μl. Conclusion: We observed no difference in aortic stiffness between HIV-infected and controls. Moreover, aortic stiffness aging was independently associated with past severe immunodeficiency, along with other traditional risk factors. Our results call for early antiretroviral initiation.
KW - Adult
KW - Aging/physiology
KW - Aorta/physiopathology
KW - Arterial Pressure
KW - CD4 Lymphocyte Count
KW - Case-Control Studies
KW - Cross-Sectional Studies
KW - Disease Progression
KW - Female
KW - HIV Infections/immunology
KW - Humans
KW - Longitudinal Studies
KW - Male
KW - Middle Aged
KW - Pulse Wave Analysis
KW - Risk Factors
KW - Smoking
KW - Vascular Stiffness
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84965025554&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/27137177
U2 - https://doi.org/10.1097/HJH.0000000000000957
DO - https://doi.org/10.1097/HJH.0000000000000957
M3 - Article
C2 - 27137177
SN - 0263-6352
VL - 34
SP - 1338
EP - 1346
JO - Journal of Hypertension
JF - Journal of Hypertension
IS - 7
ER -