Aortic thrombosis in COVID-19

Helena Wickham; Jerry C. H. Tam; Xin Hui S. Chan; Marc J. George; Marcel Levi; Michael Brown

doi:https://doi.org/10.1016/j.clinpr.2020.100059

Aortic thrombosis in COVID-19

Helena Wickham, Jerry C. H. Tam, Xin Hui S. Chan, Marc J. George, Marcel Levi, Michael Brown

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

Background: Venous thrombo-embolism is now well-recognised as a common complication of severe COVID-19 disease. Arterial thrombosis has been less well recognised, although it is increasingly reported, mostly in the context of myocardial infarction and stroke. Case report: A 63-year-old man developed a pale, cold foot with an absent dorsalis pedis pulse 7 days into his admission with COVID-19. A CT angiogram demonstrated a large thrombus in the lower thoracic aorta, which had not been present on CT pulmonary angiogram the preceding week, along with occlusion of both popliteal arteries. He was managed with therapeutic dose of low molecular weight heparin (LMWH) for 6 weeks. Results: This case adds to the growing list of potential sites and consequences of thrombosis in COVID-19. Conclusion: This case underscores the urgent need for pathophysiological studies and clinical trials to target treatments and guidelines for thromboprophylaxis in COVID-19.

Original language	English
Article number	100059
Journal	Clinical Infection in Practice
Volume	9
DOIs	https://doi.org/10.1016/j.clinpr.2020.100059
Publication status	Published - 1 Jan 2021
Externally published	Yes

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title = "Aortic thrombosis in COVID-19",

abstract = "Background: Venous thrombo-embolism is now well-recognised as a common complication of severe COVID-19 disease. Arterial thrombosis has been less well recognised, although it is increasingly reported, mostly in the context of myocardial infarction and stroke. Case report: A 63-year-old man developed a pale, cold foot with an absent dorsalis pedis pulse 7 days into his admission with COVID-19. A CT angiogram demonstrated a large thrombus in the lower thoracic aorta, which had not been present on CT pulmonary angiogram the preceding week, along with occlusion of both popliteal arteries. He was managed with therapeutic dose of low molecular weight heparin (LMWH) for 6 weeks. Results: This case adds to the growing list of potential sites and consequences of thrombosis in COVID-19. Conclusion: This case underscores the urgent need for pathophysiological studies and clinical trials to target treatments and guidelines for thromboprophylaxis in COVID-19.",

author = "Helena Wickham and Tam, {Jerry C. H.} and Chan, {Xin Hui S.} and George, {Marc J.} and Marcel Levi and Michael Brown",

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T1 - Aortic thrombosis in COVID-19

AU - Wickham, Helena

AU - Tam, Jerry C. H.

AU - Chan, Xin Hui S.

AU - George, Marc J.

AU - Levi, Marcel

AU - Brown, Michael

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Background: Venous thrombo-embolism is now well-recognised as a common complication of severe COVID-19 disease. Arterial thrombosis has been less well recognised, although it is increasingly reported, mostly in the context of myocardial infarction and stroke. Case report: A 63-year-old man developed a pale, cold foot with an absent dorsalis pedis pulse 7 days into his admission with COVID-19. A CT angiogram demonstrated a large thrombus in the lower thoracic aorta, which had not been present on CT pulmonary angiogram the preceding week, along with occlusion of both popliteal arteries. He was managed with therapeutic dose of low molecular weight heparin (LMWH) for 6 weeks. Results: This case adds to the growing list of potential sites and consequences of thrombosis in COVID-19. Conclusion: This case underscores the urgent need for pathophysiological studies and clinical trials to target treatments and guidelines for thromboprophylaxis in COVID-19.

AB - Background: Venous thrombo-embolism is now well-recognised as a common complication of severe COVID-19 disease. Arterial thrombosis has been less well recognised, although it is increasingly reported, mostly in the context of myocardial infarction and stroke. Case report: A 63-year-old man developed a pale, cold foot with an absent dorsalis pedis pulse 7 days into his admission with COVID-19. A CT angiogram demonstrated a large thrombus in the lower thoracic aorta, which had not been present on CT pulmonary angiogram the preceding week, along with occlusion of both popliteal arteries. He was managed with therapeutic dose of low molecular weight heparin (LMWH) for 6 weeks. Results: This case adds to the growing list of potential sites and consequences of thrombosis in COVID-19. Conclusion: This case underscores the urgent need for pathophysiological studies and clinical trials to target treatments and guidelines for thromboprophylaxis in COVID-19.

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VL - 9

JO - Clinical Infection in Practice

JF - Clinical Infection in Practice

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ER -

Aortic thrombosis in COVID-19

Abstract

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