@article{681409d6a2ea4ceca7b3393989c23811,
title = "APOE and immunity: Research highlights",
abstract = "INTRODUCTION: At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias. METHODS: The meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry. RESULTS: During the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]). DISCUSSION: This manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.",
keywords = "APOE, Alzheimer's disease, TREM2, amyloid beta, astrocytes, biomarkers, dementia, inflammation, microglia, neurodegeneration, neuroglia, neuroinflammation, tau",
author = "Kloske, {Courtney M.} and Barnum, {Christopher J.} and Batista, {Andre F.} and Bradshaw, {Elizabeth M.} and Brickman, {Adam M.} and Guojun Bu and Jessica Dennison and Gearon, {Mary D.} and Goate, {Alison M.} and Christian Haass and Heneka, {Michael T.} and Hu, {William T.} and Huggins, {Lenique K. L.} and Jones, {Nahdia S.} and Radosveta Koldamova and Lemere, {Cynthia A.} and Liddelow, {Shane A.} and Edoardo Marcora and Marsh, {Samuel E.} and Nielsen, {Henrietta M.} and Petersen, {Kellen K.} and Melissa Petersen and Pi{\~n}a-Escudero, {Stefanie D.} and Qiu, {Wei Qiao} and Quiroz, {Yakeel T.} and Eric Reiman and Claire Sexton and Tansey, {Mal{\'u} G. mez} and Julia Tcw and Teunissen, {Charlotte E.} and Tijms, {Betty M.} and {van der Kant}, Rik and Rebecca Wallings and Weninger, {Stacie C.} and Whitney Wharton and Wilcock, {Donna M.} and Wishard, {Tyler James} and Worley, {Susan L.} and Henrik Zetterberg and Carrillo, {Maria C.}",
note = "Funding Information: The authors would like to thank and acknowledge all conference organizers, speakers, and session chairs for your tremendous contributions to this conference. The authors would also like to thank Joanna Graca at the Alzheimer's Association for her work on this article. Courtney M. Kloske is a full-time employee of the Alzheimer's Association. Christopher J. Barnum reports in the past 36 months, grants or contracts from Alzheimer's Association, ALS Association, and the National Institutes of Health (NIH); and holds multiple patents surrounding treating neurodegenerative disease with TNF inhibitors. Andre F. Batista has nothing to disclose. Elizabeth M. Bradshaw reports in the past 36 months, grants or contracts from NIH/National Institutes on Aging (NIA) 1RF1AG058852 04/15/2018 – 03/31/2023 Bradshaw, Parkinson's Disease Foundation PF-RCE-1948 07/01/2019 – 06/30/2023 Przedborski, NIH/NIA 5R01AG067581 05/15/2020 – 01/31/2025 Bradshaw/Elyaman, NIH/NIA 5U01AG061356 09/30/2018 – 08/31/2023 Bennett/De Jager, NIH/NIA 1R21AG073882 08/15/2021 – 07/31/2023 Bradshaw, NIH/NIA 5R01AG076018 09/30/2021 – 05/31/2026 Bradshaw/Elyaman/Vardarajan, IDSA CU21-3089 01/24/2022 – 12/24/2022 Bradshaw, CZI 2021-235054 07/01/2021 – 06/30/2022 Bradshaw/Jiang; patents 2020 Rui Chang, Wassim Elyaman, Elizabeth Bradshaw, Patrick Ronaldson, Kuixi Zhu, Qianying He Compositions and Methods for Treating Neurodegenerative Disorders with NADH and/or PEITC US 63/071,032; 2021 Elizabeth Bradshaw, Wassim Elyaman Compositions and Methods for the Treatment of Alzheimer's Disease 88800730-000443. Publisher Copyright: {\textcopyright} 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",
year = "2023",
month = jun,
doi = "https://doi.org/10.1002/alz.13020",
language = "English",
volume = "19",
pages = "2677--2696",
journal = "Alzheimer s & dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "6",
}