Apoptosis and non-apoptotic deaths in cancer development and treatment response

Elza C. de Bruin; Jan Paul Medema

doi:https://doi.org/10.1016/j.ctrv.2008.07.001

Apoptosis and non-apoptotic deaths in cancer development and treatment response

Elza C. de Bruin, Jan Paul Medema

Research output: Contribution to journal › Review article › Academic › peer-review

249 Citations (Scopus)

Abstract

Resistance to apoptosis is closely linked to tumorigenesis, as it enables malignant cells to expand even in a stressful environment. Celts resistant to apoptosis are also assumed to be resistant to anti-cancer therapies. Apoptosis has therefore taken a central position in cell death research. However, its contribution to treatment success is highly debated for solid tumors. It becomes more and more clear that cells can also die by non-apoptotic mechanisms, such as autophagy, mitotic catastrophe and necrosis. In this review, we summarize the current knowledge regarding the molecular pathways that underlie these apoptotic and non-apoptotic death pathways, and discuss the clinical data that have now accumulated to evaluate their rotes in tumor development and cancer treatment. (C) 2008 Elsevier Ltd. All. rights reserved

Original language	English
Pages (from-to)	737-749
Journal	Cancer Treatment Reviews
Volume	34
Issue number	8
DOIs	https://doi.org/10.1016/j.ctrv.2008.07.001
Publication status	Published - 2008

Access to Document

https://doi.org/10.1016/j.ctrv.2008.07.001

Cite this

@article{899ba913956741e9b001715808653c90,

title = "Apoptosis and non-apoptotic deaths in cancer development and treatment response",

abstract = "Resistance to apoptosis is closely linked to tumorigenesis, as it enables malignant cells to expand even in a stressful environment. Celts resistant to apoptosis are also assumed to be resistant to anti-cancer therapies. Apoptosis has therefore taken a central position in cell death research. However, its contribution to treatment success is highly debated for solid tumors. It becomes more and more clear that cells can also die by non-apoptotic mechanisms, such as autophagy, mitotic catastrophe and necrosis. In this review, we summarize the current knowledge regarding the molecular pathways that underlie these apoptotic and non-apoptotic death pathways, and discuss the clinical data that have now accumulated to evaluate their rotes in tumor development and cancer treatment. (C) 2008 Elsevier Ltd. All. rights reserved",

author = "{de Bruin}, {Elza C.} and Medema, {Jan Paul}",

year = "2008",

doi = "https://doi.org/10.1016/j.ctrv.2008.07.001",

language = "English",

volume = "34",

pages = "737--749",

journal = "Cancer Treatment Reviews",

issn = "0305-7372",

publisher = "W.B. Saunders Ltd",

number = "8",

}

TY - JOUR

T1 - Apoptosis and non-apoptotic deaths in cancer development and treatment response

AU - de Bruin, Elza C.

AU - Medema, Jan Paul

PY - 2008

Y1 - 2008

N2 - Resistance to apoptosis is closely linked to tumorigenesis, as it enables malignant cells to expand even in a stressful environment. Celts resistant to apoptosis are also assumed to be resistant to anti-cancer therapies. Apoptosis has therefore taken a central position in cell death research. However, its contribution to treatment success is highly debated for solid tumors. It becomes more and more clear that cells can also die by non-apoptotic mechanisms, such as autophagy, mitotic catastrophe and necrosis. In this review, we summarize the current knowledge regarding the molecular pathways that underlie these apoptotic and non-apoptotic death pathways, and discuss the clinical data that have now accumulated to evaluate their rotes in tumor development and cancer treatment. (C) 2008 Elsevier Ltd. All. rights reserved

AB - Resistance to apoptosis is closely linked to tumorigenesis, as it enables malignant cells to expand even in a stressful environment. Celts resistant to apoptosis are also assumed to be resistant to anti-cancer therapies. Apoptosis has therefore taken a central position in cell death research. However, its contribution to treatment success is highly debated for solid tumors. It becomes more and more clear that cells can also die by non-apoptotic mechanisms, such as autophagy, mitotic catastrophe and necrosis. In this review, we summarize the current knowledge regarding the molecular pathways that underlie these apoptotic and non-apoptotic death pathways, and discuss the clinical data that have now accumulated to evaluate their rotes in tumor development and cancer treatment. (C) 2008 Elsevier Ltd. All. rights reserved

U2 - https://doi.org/10.1016/j.ctrv.2008.07.001

DO - https://doi.org/10.1016/j.ctrv.2008.07.001

M3 - Review article

C2 - 18722718

SN - 0305-7372

VL - 34

SP - 737

EP - 749

JO - Cancer Treatment Reviews

JF - Cancer Treatment Reviews

IS - 8

ER -