Application of the open-lung concept during positive-pressure ventilation reduces pulmonary inflammation in newborn piglets

Anton H. Van Kaam, Willem A. Dik, Jack J. Haitsma, Anne De Jaegere, Birgitta A. Naber, Wim M. Van Aalderen, Joke H. Kok, Burkhard Lachmann

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37 Citations (Scopus)

Abstract

It has been shown that application of the open-lung concept (OLC) during high-frequency oscillatory ventilation (HFOV) attenuates pulmonary inflammation. We hypothesized that this attenuation could also be achieved by applying the OLC during positive-pressure ventilation (PPV). After repeated whole-lung lavage, newborn piglets were assigned to one of three ventilation groups: (1) PPVOLC; (2) HFOVOLC, or (3) conventional PPV (PPVCON). After a ventilation period of 5 h, analysis of) bronchoalveolar lavage fluid showed a reduced influx of polymorphonuclear neutrophils, interleukin 8, and thrombin activity in both OLC groups as compared with the PPVCON group. There were no differences in tumor necrosis factor alpha levels. We conclude that application of the OLC during PPV reduces pulmonary inflammation as compared with conventional PPV and that the magnitude of this reduction is comparable to that of HFOV.

Original languageEnglish
Pages (from-to)273-280
Number of pages8
JournalBiology of the neonate
Volume83
Issue number4
DOIs
Publication statusPublished - 2003

Keywords

  • Cytokines
  • High-frequency oscillatory ventilation
  • Intermittent positive-pressure ventilation
  • Newborn piglets
  • Open-lung concept
  • Pulmonary inflammation

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