Approaches towards the synthesis of fluoro(cyclo)alkylamines

A. D. Windhorst; L. Bechger; G. W.M. Visser; W. P.M.B. Menge; R. Leurs; H. Timmerman; J. D.M. Herscheid

doi:https://doi.org/10.1016/S0022-1139(96)03457-4

Approaches towards the synthesis of fluoro(cyclo)alkylamines

A. D. Windhorst, L. Bechger, G. W.M. Visser, W. P.M.B. Menge, R. Leurs, H. Timmerman, J. D.M. Herscheid

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

The synthesis of fluoro(cyclo)alkylamines 1-amino-6-fluorohexane (1), 1-amino-7-fluoroheptane (2), cis/trans-4-fluorocyclohexylamine (3a,b) and cis-4-fluoromethylcyclohexylamine (4) has been investigated for use as synthons for histamine receptor ligands for use in PET.

Original language	English
Pages (from-to)	35-40
Number of pages	6
Journal	Journal of Fluorine Chemistry
Volume	80
Issue number	1
DOIs	https://doi.org/10.1016/S0022-1139(96)03457-4
Publication status	Published - 1 Sept 1996

Keywords

Fluorinated cyclohexylamines
Fluorination
Rapid synthesis
ω-Fluoroalkylamines

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title = "Approaches towards the synthesis of fluoro(cyclo)alkylamines",

abstract = "The synthesis of fluoro(cyclo)alkylamines 1-amino-6-fluorohexane (1), 1-amino-7-fluoroheptane (2), cis/trans-4-fluorocyclohexylamine (3a,b) and cis-4-fluoromethylcyclohexylamine (4) has been investigated for use as synthons for histamine receptor ligands for use in PET.",

keywords = "Fluorinated cyclohexylamines, Fluorination, Rapid synthesis, ω-Fluoroalkylamines",

author = "Windhorst, {A. D.} and L. Bechger and Visser, {G. W.M.} and Menge, {W. P.M.B.} and R. Leurs and H. Timmerman and Herscheid, {J. D.M.}",

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AU - Windhorst, A. D.

AU - Bechger, L.

AU - Visser, G. W.M.

AU - Menge, W. P.M.B.

AU - Leurs, R.

AU - Timmerman, H.

AU - Herscheid, J. D.M.

PY - 1996/9/1

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N2 - The synthesis of fluoro(cyclo)alkylamines 1-amino-6-fluorohexane (1), 1-amino-7-fluoroheptane (2), cis/trans-4-fluorocyclohexylamine (3a,b) and cis-4-fluoromethylcyclohexylamine (4) has been investigated for use as synthons for histamine receptor ligands for use in PET.

AB - The synthesis of fluoro(cyclo)alkylamines 1-amino-6-fluorohexane (1), 1-amino-7-fluoroheptane (2), cis/trans-4-fluorocyclohexylamine (3a,b) and cis-4-fluoromethylcyclohexylamine (4) has been investigated for use as synthons for histamine receptor ligands for use in PET.

KW - Fluorinated cyclohexylamines

KW - Fluorination

KW - Rapid synthesis

KW - ω-Fluoroalkylamines

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U2 - https://doi.org/10.1016/S0022-1139(96)03457-4

DO - https://doi.org/10.1016/S0022-1139(96)03457-4

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SP - 35

EP - 40

JO - Journal of Fluorine Chemistry

JF - Journal of Fluorine Chemistry

IS - 1

ER -

Approaches towards the synthesis of fluoro(cyclo)alkylamines

Abstract

Keywords

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