TY - JOUR
T1 - Artifact rates for 2D retinal nerve fiber layer thickness versus 3d neuroretinal rim thickness using spectral-domain optical coherence tomography
AU - Park, Elli A.
AU - Tsikata, Edem
AU - Lee, Jenny Jyoung
AU - Shieh, Eric
AU - Braaf, Boy
AU - Vakoc, Benjamin J.
AU - Bouma, Brett E.
AU - de Boer, Johannes F.
AU - Chen, Teresa C.
N1 - Funding Information: Supported by the National Institutes of Health (Award #UL1 RR025758, TCC); Massachusetts Lions Eye Research Fund (TCC); American Glaucoma Society Mid-Career Award (TCC); Fidelity Charitable Fund (Harvard University, TCC); Department of Defense Small Business Innovation Research (Topic #DHP15-016, TCC); and by a grant from the Center for Biomedical OCT Research and Translation, awarded by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health (P41EB015903, BB, BJV, BEB). The funding organizations had no role in the design or conduct of this research. Funding Information: Supported by the National Institutes of Health (Award #UL1 RR025758, TCC); Massachusetts Lions Eye Research Fund (TCC); American Glaucoma Society Mid-Career Award (TCC); Fidelity Charita-ble Fund (Harvard University, TCC); Department of Defense Small Business Innovation Research (Topic #DHP15-016, TCC); and by a grant from the Center for Biomedical OCT Research and Transla-tion, awarded by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health (P41EB015903, BB, BJV, BEB). The funding organizations had no role in the design or conduct of this research. Publisher Copyright: © 2020 The Authors. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/9
Y1 - 2020/9
N2 - Purpose: To compare the rates of clinically significant artifacts for two-dimensional peripapillary retinal nerve fiber layer (RNFL) thickness versus three-dimensional (3D) neuroretinal rim thickness using spectral-domain optical coherence tomography (SD-OCT). Methods: Only one eye per patient was used for analysis of 120 glaucoma patients and 114 normal patients. For RNFL scans and optic nerve scans, 15 artifact types were calculated per B-scan and per eye. Neuroretinal rim tissue was quantified by the minimum distance band (MDB). Global MDB neuroretinal rim thicknesses were calculated before and after manual deletion of B-scans with artifacts and subsequent automated interpo-lation. A clinically significant artifact was defined as one requiring manual correction or repeat scanning. Results: Among glaucomatous eyes, artifact rates per B-scan were significantly more common in RNFL scans (61.7%, 74 of 120) compared to B-scans in neuroretinal rim volume scans (20.9%, 1423 of 6820) (95% confidence interval [CI], 31.6–50.0; P < 0.0001). For clinically significant artifact rates per eye, optic nerve scans had significantly fewer artifacts (15.8% of glaucomatous eyes, 13.2% of normal eyes) compared to RNFL scans (61.7% of glaucomatous eyes, 25.4% of normal eyes) (glaucoma group: 95% CI, 34.1–57.5, P < 0.0001; normal group: 95% CI, 1.3–23.3, P = 0.03). Conclusions: Compared to the most commonly used RNFL thickness scans, optic nerve volume scans less frequently require manual correction or repeat scanning to obtain accurate measurements. Translational Relevance: This paper illustrates the potential for 3D OCT algorithms to improve in vivo imaging in glaucoma.
AB - Purpose: To compare the rates of clinically significant artifacts for two-dimensional peripapillary retinal nerve fiber layer (RNFL) thickness versus three-dimensional (3D) neuroretinal rim thickness using spectral-domain optical coherence tomography (SD-OCT). Methods: Only one eye per patient was used for analysis of 120 glaucoma patients and 114 normal patients. For RNFL scans and optic nerve scans, 15 artifact types were calculated per B-scan and per eye. Neuroretinal rim tissue was quantified by the minimum distance band (MDB). Global MDB neuroretinal rim thicknesses were calculated before and after manual deletion of B-scans with artifacts and subsequent automated interpo-lation. A clinically significant artifact was defined as one requiring manual correction or repeat scanning. Results: Among glaucomatous eyes, artifact rates per B-scan were significantly more common in RNFL scans (61.7%, 74 of 120) compared to B-scans in neuroretinal rim volume scans (20.9%, 1423 of 6820) (95% confidence interval [CI], 31.6–50.0; P < 0.0001). For clinically significant artifact rates per eye, optic nerve scans had significantly fewer artifacts (15.8% of glaucomatous eyes, 13.2% of normal eyes) compared to RNFL scans (61.7% of glaucomatous eyes, 25.4% of normal eyes) (glaucoma group: 95% CI, 34.1–57.5, P < 0.0001; normal group: 95% CI, 1.3–23.3, P = 0.03). Conclusions: Compared to the most commonly used RNFL thickness scans, optic nerve volume scans less frequently require manual correction or repeat scanning to obtain accurate measurements. Translational Relevance: This paper illustrates the potential for 3D OCT algorithms to improve in vivo imaging in glaucoma.
KW - Artifact
KW - Glaucoma
KW - Minimum distance band
KW - Optic nerve
KW - Optical coherence tomography
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U2 - https://doi.org/10.1167/tvst.9.10.10
DO - https://doi.org/10.1167/tvst.9.10.10
M3 - Article
C2 - 32974082
SN - 2164-2591
VL - 9
SP - 1
EP - 12
JO - Translational Vision Science and Technology
JF - Translational Vision Science and Technology
IS - 10
M1 - 10
ER -