Ascending aorta dilation in association with bicuspid aortic valve: A maturation defect of the aortic wall: a maturation defect of the aortic wall

Nimrat Grewal; Adriana C. Gittenberger-de Groot; Robert E. Poelmann; Robert J. M. Klautz; Johannes H. N. Lindeman; Marie-José Goumans; Meindert Palmen; Salah A. Mohamed; Hans-Hinrich Sievers; Ad J. J. C. Bogers; Marco C. Deruiter

doi:https://doi.org/10.1016/j.jtcvs.2014.01.027

Ascending aorta dilation in association with bicuspid aortic valve: A maturation defect of the aortic wall: a maturation defect of the aortic wall

Nimrat Grewal, Adriana C. Gittenberger-de Groot, Robert E. Poelmann, Robert J. M. Klautz, Johannes H. N. Lindeman, Marie-José Goumans, Meindert Palmen, Salah A. Mohamed, Hans-Hinrich Sievers, Ad J. J. C. Bogers, Marco C. Deruiter

Research output: Contribution to journal › Article › Academic › peer-review

70 Citations (Scopus)

Abstract

Objective: Patients with a bicuspid aortic valve have increased susceptibility to the development of ascending aortic dilation and dissection compared with persons with a tricuspid valve. To unravel a possible different mechanism underlying dilation in bicuspidy and tricuspidy, a comparison of the structure of the aortic wall was made.

Original language	English
Pages (from-to)	1583-1590
Number of pages	8
Journal	Journal of Thoracic and Cardiovascular Surgery
Volume	148
Issue number	4
DOIs	https://doi.org/10.1016/j.jtcvs.2014.01.027 https://doi.org/10.1016/j.jtcvs.2014.01.027
Publication status	Published - 2014
Externally published	Yes

Keywords

Aged
Aorta, Thoracic/pathology
Aortic Diseases/pathology
Aortic Valve/abnormalities
Bicuspid Aortic Valve Disease
Biomarkers/metabolism
Biopsy
Blotting, Western
Dilatation, Pathologic
Female
Heart Valve Diseases/pathology
Humans
Immunoenzyme Techniques
Lamin Type A/metabolism
Male
Middle Aged
Muscle, Smooth, Vascular/pathology
Nuclear Proteins/metabolism
Protein Precursors/metabolism

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Grewal, N., Gittenberger-de Groot, A. C., Poelmann, R. E., Klautz, R. J. M., Lindeman, J. H. N., Goumans, M.-J., Palmen, M., Mohamed, S. A., Sievers, H.-H., Bogers, A. J. J. C., & Deruiter, M. C. (2014). Ascending aorta dilation in association with bicuspid aortic valve: A maturation defect of the aortic wall: a maturation defect of the aortic wall. Journal of Thoracic and Cardiovascular Surgery, 148(4), 1583-1590. https://doi.org/10.1016/j.jtcvs.2014.01.027, https://doi.org/10.1016/j.jtcvs.2014.01.027

@article{b457e25de9fa4b1a8a43c84390805f70,

title = "Ascending aorta dilation in association with bicuspid aortic valve: A maturation defect of the aortic wall: a maturation defect of the aortic wall",

abstract = "Objective: Patients with a bicuspid aortic valve have increased susceptibility to the development of ascending aortic dilation and dissection compared with persons with a tricuspid valve. To unravel a possible different mechanism underlying dilation in bicuspidy and tricuspidy, a comparison of the structure of the aortic wall was made.",

keywords = "Aged, Aorta, Thoracic/pathology, Aortic Diseases/pathology, Aortic Valve/abnormalities, Bicuspid Aortic Valve Disease, Biomarkers/metabolism, Biopsy, Blotting, Western, Dilatation, Pathologic, Female, Heart Valve Diseases/pathology, Humans, Immunoenzyme Techniques, Lamin Type A/metabolism, Male, Middle Aged, Muscle, Smooth, Vascular/pathology, Nuclear Proteins/metabolism, Protein Precursors/metabolism",

author = "Nimrat Grewal and {Gittenberger-de Groot}, {Adriana C.} and Poelmann, {Robert E.} and Klautz, {Robert J. M.} and Lindeman, {Johannes H. N.} and Marie-Jos{\'e} Goumans and Meindert Palmen and Mohamed, {Salah A.} and Hans-Hinrich Sievers and Bogers, {Ad J. J. C.} and Deruiter, {Marco C.}",

note = "Publisher Copyright: {\textcopyright} 2014 The American Association for Thoracic Surgery.",

year = "2014",

doi = "https://doi.org/10.1016/j.jtcvs.2014.01.027",

language = "English",

volume = "148",

pages = "1583--1590",

journal = "Journal of Thoracic and Cardiovascular Surgery",

issn = "0022-5223",

publisher = "Mosby Inc.",

number = "4",

}

Grewal, N, Gittenberger-de Groot, AC, Poelmann, RE, Klautz, RJM, Lindeman, JHN, Goumans, M-J, Palmen, M, Mohamed, SA, Sievers, H-H, Bogers, AJJC & Deruiter, MC 2014, 'Ascending aorta dilation in association with bicuspid aortic valve: A maturation defect of the aortic wall: a maturation defect of the aortic wall', Journal of Thoracic and Cardiovascular Surgery, vol. 148, no. 4, pp. 1583-1590. https://doi.org/10.1016/j.jtcvs.2014.01.027, https://doi.org/10.1016/j.jtcvs.2014.01.027

Ascending aorta dilation in association with bicuspid aortic valve: A maturation defect of the aortic wall: a maturation defect of the aortic wall. / Grewal, Nimrat; Gittenberger-de Groot, Adriana C.; Poelmann, Robert E. et al.
In: Journal of Thoracic and Cardiovascular Surgery, Vol. 148, No. 4, 2014, p. 1583-1590.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Ascending aorta dilation in association with bicuspid aortic valve: A maturation defect of the aortic wall

T2 - a maturation defect of the aortic wall

AU - Grewal, Nimrat

AU - Gittenberger-de Groot, Adriana C.

AU - Poelmann, Robert E.

AU - Klautz, Robert J. M.

AU - Lindeman, Johannes H. N.

AU - Goumans, Marie-José

AU - Palmen, Meindert

AU - Mohamed, Salah A.

AU - Sievers, Hans-Hinrich

AU - Bogers, Ad J. J. C.

AU - Deruiter, Marco C.

PY - 2014

Y1 - 2014

N2 - Objective: Patients with a bicuspid aortic valve have increased susceptibility to the development of ascending aortic dilation and dissection compared with persons with a tricuspid valve. To unravel a possible different mechanism underlying dilation in bicuspidy and tricuspidy, a comparison of the structure of the aortic wall was made.

AB - Objective: Patients with a bicuspid aortic valve have increased susceptibility to the development of ascending aortic dilation and dissection compared with persons with a tricuspid valve. To unravel a possible different mechanism underlying dilation in bicuspidy and tricuspidy, a comparison of the structure of the aortic wall was made.

KW - Aged

KW - Aorta, Thoracic/pathology

KW - Aortic Diseases/pathology

KW - Aortic Valve/abnormalities

KW - Bicuspid Aortic Valve Disease

KW - Biomarkers/metabolism

KW - Biopsy

KW - Blotting, Western

KW - Dilatation, Pathologic

KW - Female

KW - Heart Valve Diseases/pathology

KW - Humans

KW - Immunoenzyme Techniques

KW - Lamin Type A/metabolism

KW - Male

KW - Middle Aged

KW - Muscle, Smooth, Vascular/pathology

KW - Nuclear Proteins/metabolism

KW - Protein Precursors/metabolism

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84908230479&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/24560417

U2 - https://doi.org/10.1016/j.jtcvs.2014.01.027

DO - https://doi.org/10.1016/j.jtcvs.2014.01.027

M3 - Article

C2 - 24560417

SN - 0022-5223

VL - 148

SP - 1583

EP - 1590

JO - Journal of Thoracic and Cardiovascular Surgery

JF - Journal of Thoracic and Cardiovascular Surgery

IS - 4

ER -

Grewal N, Gittenberger-de Groot AC, Poelmann RE, Klautz RJM, Lindeman JHN, Goumans MJ et al. Ascending aorta dilation in association with bicuspid aortic valve: A maturation defect of the aortic wall: a maturation defect of the aortic wall. Journal of Thoracic and Cardiovascular Surgery. 2014;148(4):1583-1590. doi: https://doi.org/10.1016/j.jtcvs.2014.01.027, https://doi.org/10.1016/j.jtcvs.2014.01.027

Ascending aorta dilation in association with bicuspid aortic valve: A maturation defect of the aortic wall: a maturation defect of the aortic wall

Abstract

Keywords

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