TY - JOUR
T1 - Assessing bone development in preterm infants using quantitative ultrasonography showed a decline in the early postnatal period
AU - Krikke, Marieke
AU - Yumani, Dana
AU - Rustenburg, Christine
AU - Cranendonk, Anneke
AU - Twisk, Jos
AU - Lafeber, Harrie
AU - van Weissenbruch, Mirjam
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Aim: Preterm infants have an insufficient bone mineral store at birth and this study explored their bone development during the early postnatal period. Methods: The metacarpal speed of sound (mcSOS) and metacarpal bone transmission time (mcBTT) were used to assess bone development in 277 preterm infants, admitted to the neonatal intensive care unit of the VU University Medical Center, Amsterdam, the Netherlands from 2007-2012. Results: During the first nine postnatal weeks, the mcSOS declined from 10 to 38 m per second per week and the mcBTT declined from 20 to 71 nanoseconds per week. The pattern of change in both of these measurements showed a significant difference between infants born before 32 weeks of gestation (p = 0.048) and those born between 28 and 32 weeks of gestation (p = 0.008). There was a borderline significant difference in the pattern of change of the mcBTT in infants with a protein intake below 2 g/kg per day versus a higher intake (p = 0.050). Conclusion: The mcSOS and mcBTT of preterm infants showed a small to moderate decline during the early postnatal period. Future studies should explore the clinical relevance of this decline and develop interventions to halt it.
AB - Aim: Preterm infants have an insufficient bone mineral store at birth and this study explored their bone development during the early postnatal period. Methods: The metacarpal speed of sound (mcSOS) and metacarpal bone transmission time (mcBTT) were used to assess bone development in 277 preterm infants, admitted to the neonatal intensive care unit of the VU University Medical Center, Amsterdam, the Netherlands from 2007-2012. Results: During the first nine postnatal weeks, the mcSOS declined from 10 to 38 m per second per week and the mcBTT declined from 20 to 71 nanoseconds per week. The pattern of change in both of these measurements showed a significant difference between infants born before 32 weeks of gestation (p = 0.048) and those born between 28 and 32 weeks of gestation (p = 0.008). There was a borderline significant difference in the pattern of change of the mcBTT in infants with a protein intake below 2 g/kg per day versus a higher intake (p = 0.050). Conclusion: The mcSOS and mcBTT of preterm infants showed a small to moderate decline during the early postnatal period. Future studies should explore the clinical relevance of this decline and develop interventions to halt it.
KW - Bone mineral store
KW - Metacarpal bone transmission time
KW - Metacarpal speed of sound
KW - Nutrition
KW - Preterm infant
UR - http://www.scopus.com/inward/record.url?scp=85032213035&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/apa.14088
DO - https://doi.org/10.1111/apa.14088
M3 - Article
C2 - 28940635
SN - 0803-5253
VL - 107
SP - 227
EP - 233
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
IS - 2
ER -