TY - JOUR
T1 - Assessing fatigue in childhood cancer survivors
T2 - Psychometric properties of the Checklist Individual Strength and the Short Fatigue Questionnaire––a DCCSS LATER study
AU - Penson, Adriaan
AU - Walraven, Iris
AU - Bronkhorst, Ewald
AU - Grootenhuis, Martha A.
AU - Tissing, Wim J. E.
AU - van der Pal, Helena J. H.
AU - de Vries, Andrica C. H.
AU - van den Heuvel-Eibrink, Marry M.
AU - Neggers, Sebastian
AU - Versluys, Birgitta A. B.
AU - Louwerens, Marloes
AU - Pluijm, Saskia M. F.
AU - Blijlevens, Nicole
AU - van der Heiden-van der Loo, Margriet
AU - Kremer, Leontien C. M.
AU - van Dulmen-den Broeder, Eline
AU - Knoop, Hans
AU - Loonen, Jacqueline
N1 - Funding Information: The authors thank all cancer survivors participating in the study and the VOKK and VOX for their contribution to the DCCSS LATER study. The authors also thank the complete LATER study group for their contribution to the study. The DCCSS LATER program was funded by KIKA/ODAS (grant 171 “DCOG LATER program”) and the Dutch Cancer Society (grant KUN 2014‐6985). Funding Information: The DCCSS LATER program was funded by KIKA/ODAS (grant 171 “DCOG LATER program”) and the Dutch Cancer Society (grant KUN 2014‐6985). Publisher Copyright: © 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
PY - 2022/2/1
Y1 - 2022/2/1
N2 - Background: Fatigue is often reported by patients with childhood cancer both during and after cancer treatment. Several instruments to measure fatigue exist, although none are specifically validated for use in childhood cancer survivors (CCS). The aim of the current study was to present norm values and psychometric properties of the Checklist Individual Strength (CIS) and Short Fatigue Questionnaire (SFQ) in a nationwide cohort of CCS. Methods: In total, 2073 participants were included from the Dutch Childhood Cancer Survivor Study (DCCSS) LATER cohort. Normative data, construct validity, structural validity, and internal consistency were calculated for the CIS and SFQ. In addition, reliability and a cutoff score to indicate severe fatigue were determined for the SFQ. Results: Correlations between CIS/SFQ and vitality measures asking about fatigue were high (>0.8). Correlations between CIS/SFQ and measures of different constructs (sleep, depressive emotions, and role functioning emotional) were moderate (0.4–0.6). Confirmatory factor analysis resulted in a four-factor solution for the CIS and a one-factor solution for the SFQ with Cronbach's alpha for each (sub)scale showing good to excellent values (>0.8). Test–retest reliability of the SFQ was adequate (Pearson's correlation = 0.88; ICC = 0.946; weighted Cohen's kappa item scores ranged 0.31–0.50) and a cut-off score of 18 showed good sensitivity and specificity scores (92.6% and 91.3%, respectively). Conclusion: The current study shows that the SFQ is a good instrument to screen for severe fatigue in CCS. The CIS can be used as a tool to assess the multiple fatigue dimensions in CCS.
AB - Background: Fatigue is often reported by patients with childhood cancer both during and after cancer treatment. Several instruments to measure fatigue exist, although none are specifically validated for use in childhood cancer survivors (CCS). The aim of the current study was to present norm values and psychometric properties of the Checklist Individual Strength (CIS) and Short Fatigue Questionnaire (SFQ) in a nationwide cohort of CCS. Methods: In total, 2073 participants were included from the Dutch Childhood Cancer Survivor Study (DCCSS) LATER cohort. Normative data, construct validity, structural validity, and internal consistency were calculated for the CIS and SFQ. In addition, reliability and a cutoff score to indicate severe fatigue were determined for the SFQ. Results: Correlations between CIS/SFQ and vitality measures asking about fatigue were high (>0.8). Correlations between CIS/SFQ and measures of different constructs (sleep, depressive emotions, and role functioning emotional) were moderate (0.4–0.6). Confirmatory factor analysis resulted in a four-factor solution for the CIS and a one-factor solution for the SFQ with Cronbach's alpha for each (sub)scale showing good to excellent values (>0.8). Test–retest reliability of the SFQ was adequate (Pearson's correlation = 0.88; ICC = 0.946; weighted Cohen's kappa item scores ranged 0.31–0.50) and a cut-off score of 18 showed good sensitivity and specificity scores (92.6% and 91.3%, respectively). Conclusion: The current study shows that the SFQ is a good instrument to screen for severe fatigue in CCS. The CIS can be used as a tool to assess the multiple fatigue dimensions in CCS.
KW - checklist individual strength
KW - childhood cancer survivors
KW - psychometric properties
KW - severe fatigue
KW - short fatigue questionnaire
UR - http://www.scopus.com/inward/record.url?scp=85121622492&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/cam4.4490
DO - https://doi.org/10.1002/cam4.4490
M3 - Article
C2 - 34953059
SN - 2045-7634
VL - 11
SP - 1172
EP - 1180
JO - Cancer Medicine
JF - Cancer Medicine
IS - 4
ER -